DCAF4: Key Regulator of Angiotensin-Converting Enzyme (G26094)

Target Name: DCAF4

NCBI ID: G26094

DCAF4: Key Regulator of Angiotensin-Converting Enzyme

Drug-induced angiotensin-converting enzyme (DCAF4) variant 3 is a protein that is expressed in various tissues of the body, including the lungs, heart, kidneys, and intestines. It is a key regulator of angiotensin-converting enzyme (ACE) activity and has been implicated in a number of diseases, including cardiovascular disease and diabetes.

Overview of DCAF4

DCAF4 is a member of the superfamily of angiotensin-converting enzymes (ACE), which are a group of enzymes that regulate the body's blood pressure. There are four different variants of DCAF4, each with a different genetic mutation that has resulted in a change in the structure and function of the enzyme.

The most common variant of DCAF4 is variant 1, which is also known as \"wild-type\" or \"parental\" variant. This variant is found in most individuals and is responsible for the majority of the activity of the enzyme. The variant is found in most individuals and is responsible for the majority of the activity of the enzyme. The wild type of DCAF4 is expressed in the heart, lungs, kidneys, and intestines and has been shown to play a role in the regulation of ion channels, including the delayed rectifier channels (IKs) that are responsible for maintaining the integrity of the heart and blood vessels.

Variant 2, also known as \"DCAF4-2,\" is a genetic variant that results in a substitution of a glutamic acid residue for a lysine residue at position 192. This substitution has resulted in a loss of function, as the substitution has changed the stability of the enzyme and reduced its ability to catalyze the conversion of angiotensin II to angiotensin III.

Variant 3, also known as \"DCAF4-3,\" is a genetic variant that results in a substitution of a lysine residue for a glutamic acid residue at position 216. This substitution has also resulted in a loss of function, as the substitution has changed the stability of the enzyme and reduced its ability to catalyze the conversion of angiotensin II to angiotensin III.

Variant 4, also known as \"DCAF4-4,\" is a genetic variant that results in a substitution of a lysine residue for a glutamic acid residue at position 208. This substitution has also resulted in a loss of function, as the substitution has changed the stability of the enzyme and reduced its ability to catalyze the conversion of angiotensin II to angiotensin III.

Expression and Function of DCAF4

DCAF4 is expressed in various tissues of the body, including the lungs, heart, kidneys, and intestines. It is primarily expressed in the heart, where it is responsible for the catalytic activity of the enzyme.

The primary function of DCAF4 is to regulate the activity of the angiotensin-converting enzyme (ACE), which is a key regulator of the body's blood pressure. When angiotensin-converting enzyme (ACE) is activated, it catalyzes the conversion of angiotensin II to angiotensin III, which causes the blood vessels to constrict and raise blood pressure.

DCAF4 is a key regulator of the activity of the angiotensin-converting enzyme (ACE), and its activity is closely monitored by the body. DCAF4 has been shown to play a role in the regulation of ion channels, including the delayed rectifier channels (IKs ) that are responsible for maintaining the integrity of the heart and blood vessels.

DCAF4 has also been shown to be involved in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is

Protein Name: DDB1 And CUL4 Associated Factor 4

Functions: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

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