Target Name: DCTN3
NCBI ID: G11258
Other Name(s): DCTN22 | DCTN3_HUMAN | dynactin subunit 3 | p22 | Dynactin subunit 3, transcript variant 1 | dynactin light chain | DCTN3 variant 1 | dynactin 3 (p22) | Dynactin subunit 3 (isoform 1) | Dynactin subunit 3 | DCTN-22 | Dynactin complex subunit 22 kDa subunit | dynactin complex subunit 22 kDa subunit

Discovery of DCTN3 as A Potential Drug Target Or Biomarker

DCTN3 (DCTN22) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the DCTN family, which includes several related proteins that play important roles in the regulation of neurotransmitter release and neurotransmission. The discovery of DCTN3 as a potential drug target or biomarker has significant implications for the treatment of various neurological and psychiatric disorders.

DCTN3 function and localization

DCTN3 is a transmembrane protein that is expressed in the brain and other tissues. It functions as a receptor for neurotransmitters, including dopamine, serotonin, and nitric oxide. DCTN3 is composed of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is involved in the formation of DCTN3 dimers, which are thought to play a role in increasing the stability and sensitivity of the receptor. The transmembrane region is responsible for the transduction of signals from the neurotransmitters to the intracellular domain, which contains the protein's active site. The intracellular domain is involved in the regulation of the intracellular signaling pathways that are involved in the neurotransmission.

DCTN3 is expressed in various tissues of the body, including the brain, heart, and kidneys. It is highly expressed in the brain, with lower levels found in the heart and kidneys. DCTN3 is also expressed in the retina, which is responsible for transmitting signals from the brain to the body. This suggests that DCTN3 may be involved in the regulation of vision and other functions that are dependent on the brain.

DCTN3 as a drug target

DCTN3 has been identified as a potential drug target due to its involvement in the regulation of neurotransmission. The neurotransmission systems that DCTN3 is involved in are known to be involved in various neurological and psychiatric disorders, including depression, anxiety, and schizophrenia.

DCTN3 has been shown to play a role in the regulation of neurotransmitter release from postsynaptic neurons. Studies have shown that DCTN3 is involved in the regulation of the release of neurotransmitters, including dopamine and serotonin, from postsynaptic neurons in the brain. This suggests that DCTN3 may be involved in the treatment of disorders that are characterized by changes in neurotransmission.

DCTN3 has also been shown to play a role in the regulation of neurotransmission in the heart and kidneys. Studies have shown that DCTN3 is involved in the regulation of neurotransmission in these tissues, which may be important for the treatment of disorders that are characterized by changes in neurotransmission.

DCTN3 as a biomarker

DCTN3 has also been identified as a potential biomarker for various neurological and psychiatric disorders. The neurotransmission systems that DCTN3 is involved in are known to be involved in the regulation of various psychiatric and neurological disorders, including depression, anxiety, and schizophrenia.

Studies have shown that DCTN3 is involved in the regulation of neurotransmission in the brain, which may be important for the treatment of these disorders. For example, studies have shown that DCTN3 is involved in the regulation of neurotransmission in the brain, which may be involved in the treatment of depression.

DCTN3 has also been shown to be involved in the regulation of neurotransmission in the heart and kidneys, which may be important for the treatment of disorders that are characterized by changes in

Protein Name: Dynactin Subunit 3

Functions: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (PubMed:9722614)

More Common Targets

DCTN4 | DCTN5 | DCTN6 | DCTPP1 | DCUN1D1 | DCUN1D2 | DCUN1D3 | DCUN1D4 | DCUN1D5 | DCX | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | DCX DET1-COP1 ubiquitin ligase complex | DCX(DCAF15) E3 protein ligase complex | DCXR | DDA1 | DDAH1 | DDAH2 | DDB1 | DDB2 | DDC | DDC-AS1 | DDD core complex | DDHD1 | DDHD2 | DDI1 | DDI2 | DDIAS | DDIT3 | DDIT4 | DDIT4L | DDN | DDO | DDOST | DDR1 | DDR2 | DDRGK1 | DDT | DDTL | DDX1 | DDX10 | DDX11 | DDX11-AS1 | DDX11L1 | DDX11L10 | DDX11L2 | DDX11L8 | DDX11L9 | DDX12P | DDX17 | DDX18 | DDX18P1 | DDX19A | DDX19A-DT | DDX19B | DDX20 | DDX21 | DDX23 | DDX24 | DDX25 | DDX27 | DDX28 | DDX31 | DDX39A | DDX39B | DDX39B-AS1 | DDX3P1 | DDX3X | DDX3Y | DDX4 | DDX41 | DDX42 | DDX43 | DDX46 | DDX47 | DDX49 | DDX5 | DDX50 | DDX50P1 | DDX51 | DDX52 | DDX53 | DDX54 | DDX55 | DDX56 | DDX59 | DDX59-AS1 | DDX6 | DDX60 | DDX60L | DDX6P1 | DEAF1 | Death-associated protein kinase | Decapping Complex | DECR1 | DECR2 | DEDD | DEDD2 | Dedicator of cytokinesis protein | DEF6 | DEF8