DO as A Potential Drug Target (G8528)

Target Name: DDO

NCBI ID: G8528

DO as A Potential Drug Target

D-aspartate oxidase (DO), also known as D-aspartate oxidase (isoform a), is an enzyme involved in the metabolism of proteins to their amino acid residues. It is a key enzyme in the 20% of protein synthesizing cells that use alternative RNA-dependent translation (ART) to synthesize proteins. In addition to its role in protein synthesis, DO is also involved in the regulation of DNA replication, apoptosis, and stress responses.

DO has been identified as a potential drug target due to its unique mechanism of action and its involvement in various cellular processes. The inhibition of DO has been shown to have therapeutic effects in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the reasons for the potential of DO as a drug target is its unique mechanism of action. DO is involved in the regulation of the stability of protein structures, which is crucial for their function. By modulating the stability of proteins, DO can affect their stability, localization, and interactions with other cellular components. This mechanism of action gives DO a unique flexibility in terms of its effects on cellular processes and functions.

DO is also involved in the regulation of DNA replication, which is a critical process for the development and maintenance of cellular genomes. In addition, DO is involved in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. Over-expression of DO has been shown to promote apoptosis in various cellular models, including cancer cells. This suggests that DO may have a role in the development and progression of cancer.

DO is also involved in the regulation of stress responses, which is crucial for the survival of cells under various stress conditions. In addition, DO is involved in the regulation of inflammation, which is a critical process for the immune response and the regulation of tissue repair.

In addition to its involvement in various cellular processes, DO is also a key enzyme in the synthesis of proteins using alternative RNA-dependent translation (ART). This means that any drugs that inhibit DO may have a significant impact on the production of proteins in cells, including those that are involved in cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, D-aspartate oxidase (DO) is a unique enzyme that is involved in the metabolism of proteins, regulation of DNA replication, apoptosis, stress responses, and protein synthesis. Its unique mechanism of action and its involvement in various cellular processes make it a potential drug target. The inhibition of DO has been shown to have therapeutic effects in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the mechanism of DO as a drug target and to develop effective therapies.

Protein Name: D-aspartate Oxidase

Functions: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate

More Common Targets