Exploring The Biology and Potential Therapeutic Applications of DEFB112

Target Name: DEFB112

NCBI ID: G245915

Exploring The Biology and Potential Therapeutic Applications of DEFB112

Defensin, beta 12 (DEFB112) is a protein that is expressed in various tissues throughout the body, including the skin, hair, nails, and bones. It is a member of the Defensin family, which is characterized by the presence of a unique C -type translocase domain in the alpha-helix region of the protein. This domain is known as the \"beta 12\" subdomain, as it is the 12th amino acid residue in the alpha-helix region.

DEFB112 has been identified as a potential drug target due to its unique biology and the involvement of various signaling pathways. In this article, we will explore the biology of DEFB112 and its potential as a drug target.

Biology of DEFB112

DEFB112 is a 21-kDa protein that is expressed in various tissues throughout the body. It is highly expressed in the skin, hair, and nails, and is also found in the bones and other tissues. DEFB112 is a member of the Defensin family, which is characterized by the presence of a unique C-type translocase domain in the alpha-helical region of the protein. This domain is known as the \"beta 12\" subdomain, as it is the 12th amino acid residue in the alpha-spiral region.

The unique C-type translocase domain in DEFB112 allows it to interact with various signaling pathways. One of the well-known interactions of DEFB112 is with the protein FBN1, which is a collagen-like protein that is expressed in the skin and other tissues. FBN1 and DEFB112 can interact and form a complex, which is involved in the regulation of cellular processes such as cell adhesion, migration, and invasion.

Another interaction of DEFB112 is with the protein PDGF2, which is a growth factor that plays a role in cell growth, differentiation, and survival. PDGF2 and DEFB112 can interact and form a complex, which is involved in the regulation of cellular processes such as cell proliferation and survival.

Potential Therapeutic Applications of DEFB112

The unique biology and interactions of DEFB112 make it an attractive drug target. DEFB112 has been shown to play a role in various cellular processes, including cell adhesion, migration, and invasion, which could make it a useful target for therapies aimed at these processes.

One therapeutic potential application of DEFB112 is in the treatment of skin diseases, such as acne and dermatitis. DEFB112 has been shown to play a role in the regulation of skin cell growth and differentiation, and could be a useful target for therapies aimed at treating skin diseases.

Another therapeutic potential application of DEFB112 is in the treatment of cancer. DEFB112 has been shown to play a role in the regulation of cell growth and survival, which could make it a useful target for therapies aimed at treating cancer.

In conclusion, DEFB112 is a protein that has unique biology and interactions, and has been identified as a potential drug target. Further research is needed to fully understand the role of DEFB112 in various cellular processes and its potential as a therapeutic target.

Protein Name: Defensin Beta 112

Functions: Has antibacterial activity

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