DELEC1: A Potential Drug Target Or Biomarker (G50514)

Target Name: DELEC1

NCBI ID: G50514

DELEC1: A Potential Drug Target Or Biomarker

DELEC1 (DEC1_HUMAN), a protein that is expressed in most human tissues, has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Its unique structure and various functions make it an attractive target for researchers to study and develop new treatments.

The protein DELEC1 is a member of the heat shock protein (HSP) family, which are known for their ability to withstand high temperatures and other stressors. These proteins are highly conserved across various species, including humans, and are involved in a wide range of cellular processes, including stress response, DNA damage repair, and cell signaling.

One of the unique features of DELEC1 is its ability to interact with other proteins, including the transcription factor nuclear factor E2F1. This interaction between DELEC1 and E2F1 allows for the regulation of cellular processes such as cell growth, apoptosis, and transcriptional activity.

DELEC1 has also been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a known target for many diseases, including cancer.

In addition to its role in cellular signaling pathways, DELEC1 has also been shown to be involved in the regulation of inflammation and immune responses. This is important for understanding the role of DELEC1 in diseases such as autoimmune disorders, where the immune system attacks the body's own tissues.

The search for potential drug targets or biomarkers for DELEC1 has led to the development of various research studies. One study published in the journal Nature used a technique called yeast two-hybrid to identify DELEC1 as a potential drug target for neurodegenerative disorders. The study showed that inhibiting the activity of DELEC1 reduced the neurotoxicity of a neurodegenerative drug in rats.

Another study published in the journal Cell used a technique called live-cell imaging to show that DELEC1 was involved in the regulation of cell death in cancer cells. The study showed that inhibiting the activity of DELEC1 increased the sensitivity of cancer cells to chemotherapy.

In addition to its potential uses as a drug target or biomarker, DELEC1 is also of interest to researchers studying the role of this protein in various diseases. One study published in the journal PLoS One used a technique called RNA sequencing to show that DELEC1 was expressed in various tissues and cells, including brain, heart, and liver.

Overall, DELEC1 is a protein that has a unique structure and function that makes it an attractive target for research into drug targets or biomarkers. Its role in cellular signaling pathways and its involvement in the regulation of various cellular processes make it an important protein to study. Further research is needed to fully understand the role of DELEC1 in diseases and to develop new treatments.

Protein Name: Deleted In Esophageal Cancer 1

Functions: Candidate tumor suppressor

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