DHRS7: A Potential Drug Target and Biomarker (G51635)

Target Name: DHRS7

NCBI ID: G51635

DHRS7: A Potential Drug Target and Biomarker

Introduction

The Dihydrolipoyl shuttle pathway (DHRS) is one of the important metabolic pathways in organisms, which plays a key role in energy metabolism, cell signaling, and cell division. In the body, short-chain fatty acids (short-chain fatty acyl-CoA) are an important source of energy, and the main enzyme that produces short-chain fatty acyl-CoA is short-chain fatty acid dehydrogenase B (DHRS7). Therefore, DHRS7 has important metabolic and functional roles in organisms.

In recent years, researchers have discovered that DHRS7 plays an important role in a variety of diseases, such as diabetes, obesity, neurodegenerative diseases, etc. In these diseases, aberrant expression or dysfunction of DHRS7 may lead to increased disease progression and severity. Therefore, DHRS7 has become the focus of many researchers and is expected to become a potential drug target for the treatment of many diseases in the future.

Function and structure of DHRS7

DHRS7 is a membrane protein that belongs to the short-chain fatty acid dehydrogenase family, which also includes members such as DHRS1, DHRS2, and DHRS3. The function of DHRS7 in vivo is to catalyze the reduction of coenzyme A to fatty acyl-CoA through short-chain fatty acid dehydrogenase activity (2), thereby producing short-chain fatty acyl-CoA as an energy source.

The structure and function of DHRS7 depend on its amino acid sequence. Similar to other short-chain fatty acid dehydrogenases, the N-terminus of DHRS7 is rich in a hydrophilic region of phenylalanine residues, which is capable of forming hydrogen bonds, thereby enhancing protein stability. In addition, the C-terminus of DHRS7 also has a catalytically active phenylalanine residue, which can serve as an active site and participate in substrate binding and reaction.

Biological functions of DHRS7

DHRS7 plays an important role in a variety of biological processes, such as cellular energy metabolism, cell signaling, cell division, etc. In the process of cellular energy metabolism, DHRS7 is a short-chain fatty acid dehydrogenase that is responsible for converting short-chain fatty acyl-CoA produced in cells into fatty acyl-CoA, thereby providing energy to cells. In addition, DHRS7 plays an important role in cell signaling. For example, in neurodegenerative diseases, abnormal expression of DHRS7 may be related to neuronal damage and apoptosis.

DHRS7 also plays an important role during cell division. Studies have shown that DHRS7 plays a role in inhibiting mitotic spindle formation in neuronal mitosis, which may have important significance for neuronal damage and treatment.

The relationship between DHRS7 and diseases

DHRS7 plays an important role in a variety of diseases, such as diabetes, obesity, neurodegenerative diseases, etc. In these diseases, aberrant expression or dysfunction of DHRS7 may lead to increased disease progression and severity.

First, DHRS7 plays an important role in diabetes. Studies have found that abnormal expression of DHRS7 is one of the important reasons for the occurrence and development of diabetes. In addition, dysfunction of DHRS7 may also be related to complications of diabetes, such as retinopathy and neuropathy.

Secondly, DHRS7 also plays an important role in obesity. Research shows that abnormal expression of DHRS7 is one of the important reasons for the occurrence and development of obesity. In addition, dysfunction of DHRS7 may also be related to complications of obesity, such as cardiovascular disease and diabetes.

Finally, DHRS7 also plays an important role in neurodegenerative diseases. Studies have found that abnormal expression of DHRS7 is one of the important reasons for the occurrence and development of neurodegenerative diseases. In addition, dysfunction of DHRS7 may also be related to complications of neurodegenerative diseases, such as neuronal damage and apoptosis.

Therefore, DHRS7, as an important biomolecule, is expected to become a potential drug target for the treatment of many diseases in the future. At the same time, research also shows that the function and structure of DHRS7 in organisms depend on its amino acid sequence, thus providing an important theoretical basis for related research.

in conclusion

DHRS7 is an important membrane protein that plays important metabolic and functional roles in organisms. Abnormal expression or abnormal function of DHRS7 is closely related to the occurrence and development of various diseases. Therefore, DHRS7 is a potential drug target and is expected to provide new ideas and methods for the treatment of many diseases.

Nonetheless, current research on DHRS7 is still in its preliminary stages. To deeply understand the function and mechanism of DHRS7 in vivo, further research and exploration are needed. At the same time, research should also focus on the functional diversity of DHRS7 and its role in different organisms and biological processes, thereby providing more accurate and comprehensive information for the development and application of DHRS7.

Protein Name: Dehydrogenase/reductase 7

Functions: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28687384, PubMed:28457967). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28687384, PubMed:28457967). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046)

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