Understanding The Versatility and Druggability of DPEP (P44944)

Target Name: Dipeptidase

NCBI ID: P44944

Other Name(s): DPEP | Dipeptidase

Understanding The Versatility and Druggability of DPEP

Dipeptidase (nonspecified subtype) (DPEP) is an enzyme that is involved in the breakdown of peptides, which are short chains of amino acids that are formed during protein synthesis. DPEP is a critical enzyme in many different biological processes, including the regulation of protein homeostasis, cell signaling, and inflammation.

One of the unique features of DPEP is its versatility. DPEP can catalyze the breakdown of a wide variety of peptides, including short peptides like histidine residues and long peptides like pro-alpha-interleukin 1 receptor (PAI-1) alpha-helical regions. This versatility makes DPEP an attractive target for drug development.

DPEP has also been shown to be involved in many different diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, DPEP has been shown to be overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This finding has led to the potential for DPEP to be used as a diagnostic or therapeutic target for these diseases.

In addition to its involvement in disease, DPEP has also been shown to have potential as a drug target. Several studies have shown that DPEP can be inhibited by small molecules, including inhibitors that target the activity of DPEP itself or its downstream substrates. These inhibitors have been shown to have a variety of different effects on cellular processes, including the regulation of protein synthesis, cell signaling, and inflammation.

One of the most promising aspects of DPEP as a drug target is its druggable nature. DPEP has a well-characterized active site that is involved in multiple important cellular processes, including protein homeostasis and cell signaling. This has made it an attractive target for the development of small molecules that can inhibit DPEP's activity.

In conclusion, Dipeptidase (nonspecific subtype) (DPEP) is an enzyme that is involved in the breakdown of peptides and has been shown to be involved in a variety of different diseases and conditions. Its versatility and druggability make it an attractive target for the development of new drugs and therapies. Further research is needed to fully understand the role of DPEP in cellular processes and its potential as a drug target.

Protein Name: Dipeptidase (nonspecified Subtype)

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