DIS3 as A Potential Drug Target (G22894)

Target Name: DIS3

NCBI ID: G22894

Other Name(s): DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, transcript variant 1 | EXOSC11 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | DIS3 homolog, exosome endoribonuclease and

DIS3 as A Potential Drug Target

DIS3 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the superfamily of intron-containing RNA-protein hybrids, also known as exoribonucleases (ERMs). ERMs are a type of transmembrane protein that belongs to the glycine-rich secretion class of proteins. These proteins are involved in the delivery of various molecules across the cell membrane, including proteins, RNA, and small molecules.

The DIS3 gene is located on chromosome 16 and encodes a protein that is characterized by its ability to catalyze the 3'-5' exoribonuclease reaction. This reaction is a key step in the regulation of gene expression, and is involved in the transfer of RNA from the cytoplasm to the nuclear matrix. In addition to its role in gene regulation, DIS3 has also been shown to play a role in the development and progression of various diseases, including cancer.

DIS3 as a drug target

DIS3 has been identified as a potential drug target due to its involvement in the regulation of gene expression and its ability to interact with various signaling pathways. Several studies have suggested that inhibiting DIS3 activity could be a useful way to treat various diseases, including cancer.

One of the potential mechanisms by which DIS3 can be targeted is its role in the regulation of cell proliferation. DIS3 has been shown to play a role in the regulation of cell cycle progression, and has been shown to interact with the protein p21. Inhibiting DIS3 activity has been shown to inhibit the growth of various cancer cell lines.

In addition to its role in cell proliferation, DIS3 has also been shown to play a role in the regulation of cell apoptosis. DIS3 has been shown to interact with the protein Bcl-2, and has been shown to regulate the expression of genes involved in cell apoptosis. Inhibiting DIS3 activity has been shown to protect cancer cells from apoptosis, a process that is often associated with the development and progression of cancer.

Another potential mechanism by which DIS3 can be targeted is its role in the regulation of gene expression. DIS3 has been shown to interact with the protein RNA-binding protein (RBP), and has been shown to regulate the activity of RBP. Inhibiting DIS3 activity has been shown to reduce the level of gene expression in various cell types, including cancer cells.

In conclusion, DIS3 is a protein that has been shown to play a role in various signaling pathways that are involved in the regulation of gene expression and cell proliferation. As a result, DIS3 has been identified as a potential drug target for the treatment of various diseases, including cancer. Further research is needed to fully understand the role of DIS3 in these processes and to develop effective treatments.

Protein Name: DIS3 Homolog, Exosome Endoribonuclease And 3'-5' Exoribonuclease

Functions: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities

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