DIS3L: Mitosis-Regulating Protein (G115752)

Target Name: DIS3L

NCBI ID: G115752

DIS3L: Mitosis-Regulating Protein

DIS3L (DIS3-like protein 3) is a protein that plays a crucial role in the regulation of mitosis, the process by which a cell divides. DIS3L is a member of the DIS3 family, which includes several proteins that share similar domains and functions. In this article, we will discuss the biology and significance of DIS3L, as well as its potential as a drug target or biomarker.

Structure and Function

DIS3L is a 21 kDa protein that contains 116 amino acid residues. It is characterized by a N-terminal alpha-helix, a central 尾-sheet, and a C-terminal T-loop. The protein has a distinct N-terminal and C -terminal region that are involved in its mitotic control function.

DIS3L functions as a regulator of mitosis by promoting the metaphase transition and preventing the progression of the G2 phase. It does this by interacting with the microtubules of the

Protein Name: DIS3 Like Exosome 3'-5' Exoribonuclease

Functions: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA

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