DMRTA1: A Potential Drug Target and Biomarker for Diseases (G63951)

Target Name: DMRTA1

NCBI ID: G63951

Other Name(s): DMRTA_HUMAN | DMO | Doublesex- and mab-3-related transcription factor A1 | DMRT4 | DMRT like family A1

DMRTA1: A Potential Drug Target and Biomarker for Diseases

DMRTA1 (DMRTA_HUMAN), a protein that belongs to the family of DNA-binding proteins known as Rb-tubulin, is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

DMRTA1 is a 21-kDa protein that is expressed in most tissues of the human body. It is primarily localized to the cytoplasm and is involved in the regulation of microtubule dynamics and stability. DMRTA1 has been shown to play a role in the development and maintenance of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of DMRTA1 is its ability to interact with microtubules. Microtubules are dynamic structures that play a critical role in the regulation of cell behavior, including cell division, intracellular transport, and signaling pathways. DMRTA1 has been shown to interact with several microtubule proteins, including TP103, TP53, and Myosin. These interactions may regulate the stability and dynamics of microtubules, which could have implications for the regulation of various cellular processes.

In cancer, DMRTA1 has been shown to be involved in the regulation of microtubule dynamics and stability, which could have implications for the development and progression of cancer. For example, DMRTA1 has been shown to be involved in the regulation of mitotic spindle formation and stability , which are critical for the development of cancer cells. Additionally, DMRTA1 has been shown to play a role in the regulation of cell adhesion and migration, which are also critical for cancer progression.

In neurodegenerative diseases, DMRTA1 has been shown to be involved in the regulation of microtubule dynamics and stability. For example, DMRTA1 has been shown to play a role in the regulation of the stability of the neurotransmitter dopamine, which is involved in various neural functions. Additionally, DMRTA1 has been shown to play a role in the regulation of the transport of neurotransmitters out of the neurons, which could contribute to neurodegenerative diseases.

In autoimmune disorders, DMRTA1 has been shown to be involved in the regulation of microtubule dynamics and stability. For example, DMRTA1 has been shown to play a role in the regulation of the formation and stability of immune cells, which are involved in autoimmune diseases. Additionally, DMRTA1 has been shown to play a role in the regulation of inflammation, which is often associated with autoimmune diseases.

In conclusion, DMRTA1 is a protein that has been shown to play a critical role in the regulation of microtubule dynamics and stability, which could have implications for the development and progression of various diseases. Further research is needed to fully understand the role of DMRTA1 in disease, including its potential as a drug target or biomarker.

Protein Name: DMRT Like Family A1

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