DNAJB6: A Drug Target / Disease Biomarker (G10049)

Target Name: DNAJB6

NCBI ID: G10049

DNAJB6: A Drug Target / Disease Biomarker

DNAJB6, also known as nuclear pore complex subunit J(P) complex subunit B6, is a protein that is expressed in most tissues of the body and is involved in various cellular processes. One of its functions is to help regulate the transport of genetic material from the nucleus to the cytoplasm, which is the fluid that surrounds the cells.

Recent studies have suggested that DNAJB6 may have potential as a drug target or biomarker. For example, some researchers have found that high levels of DNAJB6 expression are associated with poor prognosis in cancer patients, which could make it an attractive target for cancer therapies. Additionally, some studies have shown that DNAJB6 may be involved in the development and progression of neurodegenerative diseases, which could make it a useful biomarker for these conditions.

Another potential use for DNAJB6 is as a therapeutic target for diseases that involve inflammation. DNAJB6 has been shown to be involved in the regulation of immune responses and has been linked to the production of pro-inflammatory cytokines. Therefore, some researchers believe that targeting DNAJB6 with drugs that can inhibit its activity may be an effective way to treat inflammatory diseases.

In addition to its potential therapeutic uses, DNAJB6 has also been the subject of research as a potential biomarker for a number of diseases. For example, some researchers have shown that DNAJB6 levels can be used as a diagnostic marker for cancer, and that they may be able to predict the effectiveness of certain cancer therapies. Additionally, DNAJB6 has been shown to be involved in the development and progression of neurodegenerative diseases, which could make it an attractive target for diagnostic tests and therapies for these conditions.

Overall, DNAJB6 is a protein that has been studied extensively in the context of various cellular processes and has the potential to be a drug target or biomarker. Further research is needed to fully understand its functions and potential uses in disease.

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member B6

Functions: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048)

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