DOCK8: A Potential Drug Target and Biomarker for T Cell-Mediated Inherited Diseases

Target Name: DOCK8

NCBI ID: G81704

DOCK8: A Potential Drug Target and Biomarker for T Cell-Mediated Inherited Diseases

Abstract:

DOCK8, a protein that belongs to the DOCK family, has been identified as a potential drug target and biomarker for T cell-mediated inherited diseases. Its functions in cytokinesis and immune regulation make it an attractive target for small molecule inhibitors. This review summarizes the current research on DOCK8 and its potential as a drug target and biomarker for T cell-mediated inherited diseases.

Introduction:

Inherited diseases are a major burden on human health, affecting millions of individuals worldwide. Many of these diseases are caused by mutations in genes that regulate essential cellular processes, including cytokinesis and immune regulation. The DOCK family of proteins plays a critical role in these processes, and DOCK8 is a key member of this family.

Recent studies have identified DOCK8 as a potential drug target and biomarker for T cell-mediated inherited diseases. Its functions in cytokinesis and immune regulation make it an attractive target for small molecule inhibitors. In this review, we will summarize the current research on DOCK8 and its potential as a drug target and biomarker for T cell-mediated inherited diseases.

DOCK8: A Protein of the DOCK Family

The DOCK family of proteins consists of six members: DOCK1, DOCK2, DOCK3, DOCK4, DOCK5, and DOCK6. They share a conserved catalytic core and a similar structure, with each member having a unique N-terminal and C-terminal region. The DOCK8 protein, also known as Dedicator of cytokinesis 8, is a member of the DOCK family and has the same conserved catalytic core and structure as the other members of the family.

DOCK8 Functions in Cytokinesis and Immune Regulation

DOCK8 is involved in the regulation of cytokinesis, the process by which eukaryotic cells produce and differentiate into different cell types. During cytokinesis, DOCK8 plays a critical role in the organization of the cytoskeleton and the formation of new cytoskeleton in the cytoplasm.

In addition to its role in cytokinesis, DOCK8 is also involved in immune regulation. It has been shown to be involved in the regulation of T cell development, activation, and function. DOCK8 has also been shown to play a role in the regulation of inflammation and immune cell homeostasis.

Potential as a Drug Target

DOCK8 has been identified as a potential drug target for T cell-mediated inherited diseases. Its functions in cytokinesis and immune regulation make it an attractive target for small molecule inhibitors. In fact, several studies have shown that inhibitors of DOCK8 can suppress the development and function of T cells, leading to a reduction in the severity of T cell-mediated inherited diseases.

DOCK8 has also been shown to play a role in the regulation of cellular signaling pathways, including the JAK/STAT signaling pathway. This pathway is involved in the regulation of immune cell function and has been implicated in the development of several T cell-mediated inherited diseases, including systemic lupus erythematosus and multiple sclerosis.

Potential as a Biomarker

DOCK8 has also been identified as a potential biomarker for T cell-mediated inherited diseases. Its functions in cytokinesis and immune regulation make it an attractive target for diagnostic assays, such as flow cytometry, gene expression profiling, and DNA sequencing.

Studies have shown that DOCK8 levels can be accurately measured using these assays, and that they can be used as biomarkers for the diagnosis of T cell-mediated inherited diseases. For example,

Protein Name: Dedicator Of Cytokinesis 8

Functions: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780)

More Common Targets