DPPA5P4: A Potential Drug Target and Biomarker for Developed-Expression-Associated Pseudogene

Target Name: DPPA5P4

NCBI ID: G646701

Other Name(s): Developmental pluripotency associated 5 pseudogene | developmental pluripotency associated 5 pseudogene 4 | LOC646701

DPPA5P4: A Potential Drug Target and Biomarker for Developed-Expression-Associated Pseudogene

Introduction

Pseudogenes are aberrant genes that have been expressed in the body but have not been true functional genomes. These pseudogenes can be generated through various mechanisms, including gene fusions, insertions, deletions, and mutations. Pseudogenes are often associated with developmental plasticity and can play a role in the development and progression of various diseases. One of the striking classes of pseudogenes is Developmental Pluripotency Associated Pseudogene (DPPA5P4), also known as developmental plasticity associated pseudogene. DPPA5P4 is widely expressed in adults, ranging from regulating cell cycle to participating in immune responses to affecting the development and function of the nervous system. Increasing evidence shows that DPPA5P4 plays an important role in many diseases, including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders. Therefore, DPPA5P4 has become a subject of much attention and may become a potential drug target or biomarker.

Expression and function of DPPA5P4

DPPA5P4 is an 11.1 kb DNA fragment located in the human genome at HGNC RefSeq HGNC118.287. The gene coding region of DPPA5P4 includes an open reading frame (ORF) and an N-terminal gene silencing element. ORF includes a typical coding region, including a conserved DNA binding region and a TATA binding region, which play key roles in the transcription and translation processes. The N-terminal gene silencing element is a gene silencing element composed of 12 non-coding RNAs located at the N-terminus of the ORF.

The DPPA5P4 gene is widely expressed in various tissues and organs. In adults, DPPA5P4 is expressed in multiple cell types, including neurons, glial cells, dermal blasts, hepatocytes, and immune system cells. In tumors, DPPA5P4 expression levels are also higher. The expression level of DPPA5P4 is closely related to tissue proliferation, differentiation, apoptosis and other life processes.

The function of DPPA5P4 has been extensively studied. From cell cycle regulation to immune response to nervous system development and function, DPPA5P4 plays an important role in multiple physiological processes. In cell cycle regulation, DPPA5P4 binds to CDK4 and CDK6 and is involved in mitotic progression and arrest. In the immune response, DPPA5P4 binds to PD-L1 and promotes immune cells to inhibit tumor growth. In the development and function of the nervous system, DPPA5P4 is involved in neuronal proliferation, differentiation, and apoptosis, as well as synaptic plasticity between neurons.

Mechanism of action of DPPA5P4

The mechanism of action of DPPA5P4 is not fully understood, but some important discoveries have been made. Evidence shows that DPPA5P4 plays an important role in many diseases, including cancer, neurodegenerative diseases, autoimmune diseases, and metabolic disorders.

First, DPPA5P4 is closely related to the occurrence and development of many diseases. For example, DPPA5P4 is expressed at higher levels in many cancers and is associated with tumor invasion and metastasis capabilities. In addition, DPPA5P4 is also associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In autoimmune diseases, DPPA5P4 is associated with an increased risk of many autoimmune diseases, such as rheumatoid arthritis, autoimmune hepatitis, etc.

Secondly, the mechanism of action of DPPA5P4 may involve regulating intracellular signaling pathways. For example, DPPA5P4 can phosphorylate PD-L1, thereby enhancing the effects of PD-L1. In addition, DPPA5P4 can also bind to receptors on neurons, such as TrkB, thereby participating in synaptic plasticity between neurons.

Finally, DPPA5P4 may serve as a potential drug target. More and more studies have shown that DPPA5P4 plays an important role in drug anti-tumor

Protein Name: Developmental Pluripotency Associated 5 Pseudogene 4

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