DOK2: Key Regulator of Cell Proliferation and Disease (G9046)

Target Name: DOK2

NCBI ID: G9046

DOK2: Key Regulator of Cell Proliferation and Disease

DOK2 (p56DOK) is a protein that is expressed in various tissues of the body, including the brain, pancreas, and gastrointestinal tract. It is a key regulator of cell proliferation and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the defining features of DOK2 is its role in the regulation of the p56 gene, which encodes a protein that is involved in a variety of cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. The p56 gene is a highly conserved gene that is expressed in many different organisms, including humans.

DOK2 has been shown to play a critical role in the regulation of cell proliferation and has been implicated in the development and progression of a number of diseases. For example, studies have shown that high levels of DOK2 are associated with the development of cancer, including breast, ovarian, and prostate cancer. Additionally, DOK2 has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

DOK2 has also been shown to be involved in the regulation of inflammation, which is a critical aspect of many diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. For example, studies have shown that DOK2 is involved in the regulation of the production of pro-inflammatory cytokines, which are involved in the recruitment of immune cells to the site of inflammation and the initiation of an inflammatory response.

In addition to its role in cell proliferation and inflammation, DOK2 has also been shown to be involved in the regulation of cell death, which is a critical aspect of many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that DOK2 is involved in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death.

DOK2 has also been shown to play a critical role in the regulation of stem cell proliferation and maintenance. Stem cells are a critical source of cells that have the ability to regenerate and repair damaged tissues, and the regulation of stem cell proliferation and maintenance is essential for the development and maintenance of tissues and organs.

In conclusion, DOK2 is a protein that has been shown to play a critical role in the regulation of cell proliferation, inflammation, and cell death. Its role in these processes makes DOK2 an attractive target for drug development, particularly for the treatment of diseases associated with these processes, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of DOK2 in these processes and to develop effective treatments.

Protein Name: Docking Protein 2

Functions: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)

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