Identification of DPH6 as A Potential Drug Target (G89978)

Target Name: DPH6

NCBI ID: G89978

Identification of DPH6 as A Potential Drug Target

DPH6 is a protein that is expressed in various tissues of the body, including the brain, spleen, and Peyer's patches. It is a member of the heat shock protein (HSP) family and is involved in the regulation of cellular stress responses. Despite its importance in cellular stress management, DPH6 has not yet been identified as a drug target or biomarker.

The search for DPH6 as a drug target or biomarker began with the identification of its potential interacting proteins. One of these proteins is the heat shock protein (HSP) protein DPH6.6, which is a critical protein for the regulation of cellular stress responses. DPH6.6 is a subunit of the HSP70 family and is highly conserved in various species, including humans.

Expression and localization of DPH6

DPH6 is expressed in various tissues of the body, including the brain, spleen, and Peyer's patches. The brain is a common site for DPH6 expression, and DPH6.6 is highly expressed in the brain, specifically in the peri-synaptic protein (PSP) positive cell types, including astrocytes and oligodendrocytes. DPH6.6 is also expressed in the white blood cells, including neutrophils, and in the epithelial tissue, including the breast epithelial cells.

In addition to its expression in various tissues, DPH6 has also been shown to localize to specific cellular structures. DPH6.6 has been shown to localize to the endoplasmic reticulum (ER) and to be involved in the ER-associated degradation (ERAD) of protein species. DPH6.6 has also been shown to localize to the cytoplasm and to be involved in the regulation of cellular processes, including the cell cycle and the production of mitochondrial products.

Function and role in cellular stress management

DPH6 is involved in the regulation of cellular stress responses, including the regulation of inflammation and the response to oxidative stress. DPH6.6 has been shown to play a role in the regulation of inflammation in various cell types, including immune cells and neuroendocrine cells. DPH6.6 has also been shown to play a role in the regulation of cellular responses to oxidative stress, including the production of reactive oxygen species (ROS) and the detoxification of ROS.

In addition to its role in cellular stress management, DPH6 is also considered a potential drug target. The high conservation nature of DPH6.6, as well as its involvement in cellular stress management, makes it an attractive candidate for drug targeting.

Conclusion

DPH6 is a protein that is expressed in various tissues of the body and is involved in the regulation of cellular stress responses. Its localization to specific cellular structures and its involvement in the regulation of cellular stress management make it an attractive candidate for drug targeting. Further research is needed to determine the full function and role of DPH6 as a drug target or biomarker.

Protein Name: Diphthamine Biosynthesis 6

Functions: Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP (PubMed:23169644). Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity)

More Common Targets