DPP6: A Promising Drug Target / Biomarker (G1804)

Target Name: DPP6

NCBI ID: G1804

DPP6: A Promising Drug Target / Biomarker

DPP6 is a protein that is expressed in various tissues throughout the body. It is a key regulator of the mitotic spindle, which is a structure that pulls the chromosomes apart during cell division. DPP6 has also been shown to play a role in the regulation of cell survival and the development of cancer. As a result, DPP6 has potential as a drug target or biomarker.

DPP6 as a Drug Target

DPP6 has been shown to be involved in a variety of cellular processes that are important for cancer development. One of the most well-studied functions of DPP6 is its role in the regulation of the mitotic spindle. The mitotic spindle is a complex structure that pulls the chromosomes apart during cell division. DPP6 is shown to be involved in the regulation of the length of the spindle, as well as the stability of the spindle.

In addition to its role in the regulation of the mitotic spindle, DPP6 has also been shown to be involved in the regulation of cell survival. DPP6 has been shown to play a role in the regulation of cell cycle progression, as well as the regulation of apoptosis, or cell death.

DPP6 as a Biomarker

DPP6 has also been shown to be a potential biomarker for cancer. DPP6 has been shown to be expressed in a variety of cancer types, including breast, ovarian, and colorectal cancer. Additionally, studies have shown that DPP6 levels are often elevated in cancer tissues compared to healthy tissue. This suggests that DPP6 may be a useful biomarker for cancer diagnosis and monitoring.

DPP6 as a Potential Therapy

DPP6 has also been shown to be a potential target for small molecule inhibitors. One of the most well-studied small molecules that is known to inhibit DPP6 is the drug BHQ121. BHQ121 is a small molecule that is shown to inhibit the activity of DPP6, and has been shown to be effective in treating breast cancer.

In addition to its potential as a drug target, DPP6 has also been shown to be a potential biomarker for cancer. DPP6 has been shown to be expressed in a variety of cancer types, including breast, ovarian, and colorectal cancer. Additionally, studies have shown that DPP6 levels are often elevated in cancer tissues compared to healthy tissue. This suggests that DPP6 may be a useful biomarker for cancer diagnosis and monitoring.

Conclusion

DPP6 is a protein that is expressed in various tissues throughout the body. It is a key regulator of the mitotic spindle, as well as the regulation of cell survival and the development of cancer. As a result, DPP6 has potential as a drug target or biomarker. The drug BHQ121 is currently being studied as a potential small molecule inhibitor of DPP6. Further research is needed to fully understand the role of DPP6 in cancer development and treatment.

Protein Name: Dipeptidyl Peptidase Like 6

Functions: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821)

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