DNMT3B: A Drug Target and Potential Biomarker (G1789)

Target Name: DNMT3B

NCBI ID: G1789

DNMT3B: A Drug Target and Potential Biomarker

DNA damage repair (DNA repair) is a crucial process in maintaining cellular health. DNA damage can result from various factors, including mutations, UV radiation, and chemical stressors. In response to these stimuli, the DNA damage repair pathway is activated to repair the damage and maintain genomic integrity. The DNA damage repair pathway is a complex series of cellular pathways that involve various proteins and enzymes. One of the key proteins involved in this pathway is DNA non-coding RNA-binding protein 3 (DNMT3B).

DNMT3B: Structure and Function

DNMT3B is a protein that belongs to the IMP family of proteins. These proteins are involved in the repair of DNA damage by specifically binding to the template strand of a double-stranded DNA break. DNMT3B is composed of 193 amino acid residues and has a calculated molecular weight of 21 kDa.

DNMT3B plays a crucial role in the DNA damage repair pathway by binding to the double-stranded break site. It does this by using a unique domain that consists of a nucleotide-binding oligomerization (NBO) domain and a T-loop domain. The NBO domain is responsible for binding to the single-stranded DNA template, while the T-loop domain is involved in the formation of a stable complex with the template strand.

In addition to its role in DNA damage repair, DNMT3B has also been shown to play a key role in the regulation of gene expression. DNMT3B has been shown to interact with several transcription factors, including ATF-2, p53, and HIF1伪. These interactions allow DNMT3B to regulate the expression of target genes and to play a role in the regulation of cellular processes such as cell growth, apoptosis, and DNA repair.

DNMT3B as a Drug Target

DNMT3B has been identified as a potential drug target due to its involvement in the regulation of cellular processes that are relevant to a variety of diseases. One of the potential applications of DNMT3B as a drug target is its role in the treatment of DNA damage-related diseases, such as cancer.

DNMT3B has been shown to play a role in the regulation of the DNA damage repair pathway in cancer cells. In fact, DNMT3B has been shown to be involved in the repair of DNA double-strand breaks in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that DNMT3B may be a useful target for the development of cancer therapies that target the DNA damage repair pathway.

In addition to its potential use in cancer therapy, DNMT3B has also been identified as a potential biomarker for the detection of DNA damage in various types of cancer. This is because DNMT3B has been shown to be expressed in a variety of cancer types, including breast, ovarian, and colorectal cancers. The expression of DNMT3B in these cancers could be used as a biomarker for the diagnosis and monitoring of these diseases.

Conclusion

DNMT3B is a protein that plays a crucial role in the DNA damage repair pathway. It is involved in the regulation of cellular processes that are relevant to a variety of diseases, including cancer. In addition to its potential use as a drug target, DNMT3B has also been identified as a potential biomarker for the detection of DNA damage in various types of cancer. Further research is needed to fully understand the role of DNMT3B in these processes and to develop effective therapies that target this protein.

Protein Name: DNA Methyltransferase 3 Beta

Functions: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398)

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