DNAH6: A Potential Drug Target and Biomarker (G1768)

Target Name: DNAH6

NCBI ID: G1768

DNAH6: A Potential Drug Target and Biomarker

DNAh6 is a double-stranded DNA fragment that is derived from the nuclear matrix of human cancer cells. It has been shown to be highly expressed in various types of cancer, including breast, ovarian, and colorectal cancers. The unique structure of DNAh6 has led to its potential as a drug target or biomarker. In this article, we will discuss the properties of DNAh6, its potential drug targets, and its potential as a biomarker for cancer diagnosis and treatment.

Properties of DNAh6

DNAh6 is a double-stranded DNA fragment that is typically 100-300 base pairs in length. It is derived from the nuclear matrix of human cancer cells and has a unique structure that allows it to interact with certain proteins. DNAh6 has a circular shape with a T-loop region at one end and a G-loop region at the other end. The T-loop region is composed of alternating A-T and G-C base pairs, while the G-loop region is composed of alternating G-C and A-T base pairs.

DNAh6 has been shown to be highly expressed in various types of cancer, including breast, ovarian, and colorectal cancers. It has also been shown to be associated with the development of cancer-invariant stem cells (CISCs), which are cells that have the ability to maintain a stem cell-like state and have the potential to develop into various types of cancer.

Potential Drug Targets

DNAh6 has been shown to interact with several proteins, including the transcription factor NF-kappa-B. NF-kappa-B is a protein that plays a role in cell signaling and is known to promote the development of cancer. By interacting with NF-kappa-B, DNAh6 has been shown to promote the growth and survival of cancer cells.

Additionally, DNAh6 has been shown to interact with the protein PDGF-BB, which is a key regulator of cell signaling and growth. The interaction between DNAh6 and PDGF-BB has been shown to promote the development of cancer.

Potential Biomarkers

DNAh6 has been shown to be a potential biomarker for cancer diagnosis and treatment. Its unique structure and association with cancer cells make it an attractive candidate for use as a biomarker. Additionally, the high expression of DNAh6 in various types of cancer makes it a promising candidate for use as a diagnostic biomarker.

In conclusion, DNAh6 is a double-stranded DNA fragment that is derived from the nuclear matrix of human cancer cells. Its unique structure and association with cancer cells make it a potential drug target or biomarker. Further research is needed to fully understand the properties of DNAh6 and its potential as a drug or biomarker.

Protein Name: Dynein Axonemal Heavy Chain 6

Functions: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity)

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