DNAJB2: A Potential Drug Target and Biomarker for DNA Damage Response and Cellular Stress

Target Name: DNAJB2

NCBI ID: G3300

DNAJB2: A Potential Drug Target and Biomarker for DNA Damage Response and Cellular Stress

DNA damage response (DDR) is a critical cellular process that ensures the integrity of DNA and protects against genetic alterations, thereby maintaining cellular health and diversity. DNAJB2 (DnaJ heat shock protein family (Hsp40) member B2, transcript variant 2) is a protein that plays a crucial role in the DDR pathway, specifically in the response to DNA damage. In this article, we will discuss DNAJB2 as a drug target and biomarker, highlighting its potential clinical applications in the field of genetics and neuroscience.

Structure and Function

DNAJB2, also known as HSP70B2, is a 43kDa heat shock protein that belongs to the DNAJB2 family of proteins. The DNAJB2 gene was identified as a gene that is involved in various cellular processes, including DNA replication, repair, and protection against various types of stress, including heat stress, radiation stress, and chemical stress.

DNAJB2 is a protein that can form a stable complex with the transcription factor, p53, leading to the formation of the DNAJB2-p53 complex. This complex plays a crucial role in regulating DNA damage repair processes, including the DNA double-strand break repair pathway.

DNAJB2 is also involved in the regulation of cellular stress responses, including the production of reactive oxygen species (ROS) and the production of proteinases, such as DNA damage-inducible gene 1 (PDGF), which can cause cellular stress and contribute to the development of various diseases, including cancer.

Mutations in the DNAJB2 gene have been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, there is a growing interest in developing drugs that target DNAJB2 as a potential therapeutic approach for these diseases.

Drug Target Potential

DNAJB2 has been identified as a potential drug target due to its involvement in the DDR pathway and its role in the regulation of cellular stress responses. Several studies have shown that inhibiting the activity of DNAJB2 can lead to a reduction in the formation of ROS and DNA damage repair, thereby inhibiting the development of various diseases.

One of the potential strategies for targeting DNAJB2 is the use of small molecules, such as inhibitors of the protein stability of DNAJB2, which can disrupt its association with p53 and prevent the formation of the DNAJB2-p53 complex.

Another approach to targeting DNAJB2 is the use of antibodies that specifically recognize and target the protein. This approach has been used to target DNAJB2 in various cellular models, including cancer cells, and has shown promise in preclinical studies.

Biomarker Potential

DNAJB2 has also been identified as a potential biomarker for various diseases, including cancer. The DNAJB2 gene has been shown to be involved in the regulation of DNA replication, repair, and the response to DNA damage, which are critical processes for the development and progression of cancer.

Therefore, the expression of DNAJB2 has been used as a biomarker for various types of cancer, including breast, ovarian, and colorectal cancers. Studies have shown that higher expression of DNAJB2 is associated with a more aggressive and relapse-prone phenotype in cancer cells.

Conclusion

In conclusion, DNAJB2 is a protein that plays a crucial role in the DDR pathway and is involved in the regulation of various cellular processes, including DNA replication, repair, and stress responses. Its involvement in these processes makes it a potential drug target and biomarker for various diseases, including cancer. Further research is needed to fully understand the role of DNAJB2 in

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member B2

Functions: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278)

More Common Targets