DNAH10: A Potential Drug Target and Biomarker (G196385)

Target Name: DNAH10

NCBI ID: G196385

DNAH10: A Potential Drug Target and Biomarker

DNAH10 is a gene that encodes a protein known as doublecortin (DCN), which is a nuclear protein that plays a critical role in the regulation of stem cell proliferation and differentiation. The identification of DNAH10 as a potential drug target and biomarker has significant implications for the development of new therapeutic approaches for a variety of diseases.

The Protein encoded by DNAH10

DNAH10 encodes a 15kDa protein that is expressed in various tissues and cells, including the brain, pancreas, and gastrointestinal tract. The protein is composed of multiple domains, including an N-terminus, a catalytic domain, and a C-terminus. The N-terminus of DNAH10 contains a 25 amino acid residue that is rich in electrostatic potential and is known as the N-terminal hypervariable region (N-VAR).

The DCN protein function

DCN is a key regulator of stem cell proliferation and differentiation. It is expressed in various tissues and cells and plays a critical role in the regulation of cell growth, apoptosis, and angiogenesis. DCN functions by binding to DNA and modulating the expression of genes that are involved in cell growth and differentiation.

DNAH10 functions as a negative regulator of DCN

DNAH10 functions as a negative regulator of DCN by binding to its N-VAR and preventing it from binding to DNA. This interaction between DNAH10 and DCN is critical for the regulation of stem cell proliferation and differentiation.

Mutations in DNAH10 gene

Mutations in the DNAH10 gene have been identified that are associated with a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. These mutations have been shown to alter the function of DNAH10 and disrupt its ability to regulate DCN.

Potential Therapeutic Applications

The identification of DNAH10 as a potential drug target and biomarker has significant implications for the development of new therapeutic approaches for a variety of diseases. Some potential therapeutic applications of DNAH10 include:

1. Cancer therapeutic applications: DNAH10 has been shown to play a critical role in the regulation of stem cell proliferation and differentiation, which makes it an attractive target for cancer therapies. Drugs that target DNAH10 have the potential to inhibit stem cell proliferation and differentiate, leading to a reduction in cancer cell growth.
2. Neurodegenerative diseases therapeutic applications: DNAH10 has been shown to play a critical role in the regulation of neurotransmitter synthesis and release, which makes it an attractive target for neurodegenerative diseases. Drugs that target DNAH10 have the potential to treat a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.
3. Autoimmune diseases therapeutic applications: DNAH10 has been shown to play a critical role in the regulation of immune cell function, which makes it an attractive target for autoimmune diseases. Drugs that target DNAH10 have the potential to treat a variety of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis.

Conclusion

DNAH10 is a gene that encodes a protein that is expressed in various tissues and cells and plays a critical role in the regulation of stem cell proliferation and differentiation. The identification of DNAH10 as a potential drug target and biomarker has significant implications for the development of new therapeutic approaches for a variety of diseases. Further research is needed to fully understand the function of DNAH10 and its potential as a drug target and biomarker.

Protein Name: Dynein Axonemal Heavy Chain 10

Functions: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (PubMed:34237282). Probable inner arm dynein heavy chain

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