DNAH3: A Potential Drug Target and Biomarker (G55567)

Target Name: DNAH3

NCBI ID: G55567

DNAH3: A Potential Drug Target and Biomarker

DNAH3 (Dnahc3-b) is a protein that is expressed in various tissues and cells of the human body. It is a key regulator of the DNA double helix and has been implicated in various cellular processes, including DNA replication, repair, and apoptosis. DNAH3 has also been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Importance of DNAH3

DNAH3 is a critical regulator of the DNA double helix, which is the fundamental structure of all life. DNAH3 plays a vital role in ensuring the stability and integrity of the double helix, by regulating the movement of DNA nucleotides along the strand. It does this by interacting with a variety of different proteins, including the DNA-binding protein p53, which is a well-known regulator of DNA replication and repair.

DNAH3 is also involved in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. DNAH3 has been shown to play a role in the regulation of apoptosis, by interacting with the protein Bcl-2. Bcl-2 is a protein that has been implicated in the regulation of apoptosis, and it is thought to work by inhibiting the production of pro-apoptotic proteins.

Potential Drug Target

DNAH3 has been identified as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. One of the reasons for its potential as a drug target is its involvement in the regulation of cell proliferation and apoptosis.

For example, studies have shown that high levels of DNAH3 are associated with the development of cancer. This is because increased levels of DNAH3 can lead to the production of pro-inflammatory cytokines, which can promote the growth and proliferation of cancer cells. Additionally, DNAH3 has been shown to play a role in the regulation of apoptosis, and it is thought to contribute to the development of neurodegenerative diseases.

Biomarker

DNAH3 has also been identified as a potential biomarker for a variety of diseases. For example, studies have shown that levels of DNAH3 are elevated in the brains of individuals with Alzheimer's disease, a neurodegenerative disorder. Additionally, DNAH3 has been shown to be elevated in the blood of individuals with multiple sclerosis, an autoimmune disorder.

Conclusion

In conclusion, DNAH3 is a protein that is expressed in various tissues and cells of the human body and plays a critical role in the regulation of the DNA double helix. It is also a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of DNAH3 in these diseases and to develop effective treatments.

Protein Name: Dynein Axonemal Heavy Chain 3

Functions: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)

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