DNAH2: A Potential Drug Target Or Biomarker for Various Diseases

Target Name: DNAH2

NCBI ID: G146754

DNAH2: A Potential Drug Target Or Biomarker for Various Diseases

DNAH2, also known as ciliary dynein heavy chain 2, is a protein that is expressed in the ciliated epithelial cells of the human body. It plays a crucial role in the structure and function of ciliated epithelial cells, which are responsible for maintaining the proper barrier function in the body.

Recent studies have identified DNAH2 as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and respiratory diseases. This is due to its unique structure and function, as well as its expression pattern in different tissues and diseases.

DNAH2 is a member of the dynein family, which is a group of transmembrane proteins that are involved in the transport of organelles and vesicles in cells. The dynein family includes four subfamilies, including the heavy chain subfamily, which is responsible for the overall structure of the protein.

The ciliary epithelial cell is a type of epithelial cell that is located in the lining of the eye and respiratory tract. These cells are known for their ability to move small particles out of the body through cc cilia, which are organized in a hexagonal pattern. DNAH2 is one of the proteins that is involved in the structure and function of these cilia.

DNAH2 is composed of 19 kDa of protein and 4 kDa of a N-terminal domain. The protein has a characteristic X-shaped structure, with a long amino terminal domain and a short carboxy terminal domain. The middle region of the protein contains a series of repeating and alternating beta-strands, which give the protein its characteristic X-shaped shape.

One of the most interesting features of DNAH2 is its ability to interact with other proteins. Studies have shown that DNAH2 can interact with a variety of proteins, including the cytoskeleton, adhesion molecules, and signaling proteins. This interaction between DNAH2 and other proteins is important for its function in maintaining the structure and function of ciliated epithelial cells.

In addition to its role in the structure and function of ciliated epithelial cells, DNAH2 has also been shown to be involved in several cellular processes. For example, studies have shown that DNAH2 is involved in the regulation of cell adhesion, cell migration, and the formation of tight junctions. It has also been shown to play a role in the regulation of ion and water transport, as well as in the regulation of gene expression.

DNAH2 has also been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and respiratory diseases. For example, studies have shown that DNAH2 is overexpressed in several types of cancer, including breast, ovarian, and prostate cancer. This increase in DNAH2 expression is associated with the development of cancer-related symptoms, such as increased invasiveness and metastasis.

In addition to its involvement in cancer, DNAH2 has also been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Studies have shown that DNAH2 is overexpressed in the brains of individuals with these conditions, and that this increase in DNAH2 expression is associated with the progression of the disease.

Finally, DNAH2 has also been shown to be involved in the development and progression of respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Studies have shown that DNAH2 is overexpressed in the lungs of individuals with these conditions, and that this increase in DNAH2 expression is associated with the development of respiratory symptoms.

In conclusion, DNAH2 is a protein that is expressed in the cilled epithelial cells of the human body. It plays a crucial role in the structure and function of these cells, and is involved in several cellular processes, including cell

Protein Name: Dynein Axonemal Heavy Chain 2

Functions: As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583)

More Common Targets