DHX16: A Non-Coding RNA Molecule as A Potential Drug Target (G8449)

Target Name: DHX16

NCBI ID: G8449

DHX16: A Non-Coding RNA Molecule as A Potential Drug Target

DHX16 (doublecortin) is a non-coding RNA molecule that has been identified as a potential drug target (DMT) and biomarker for various psychiatric and neurological disorders, including depression, anxiety, and schizophrenia. Its function and structure have been extensively studied, and its potential as a drug target continues to attract research interest.

DHX16 is a small non-coding RNA molecule that is expressed in various tissues and cells throughout the body. It is characterized by its unique structure, which consists of a hairpin-like domain and a 3' end that is conserved across different species. DHX16 is highly expressed in the brain and other central nervous system (CNS) tissues, and its levels have been linked to various psychiatric and neurological disorders.

One of the key functions of DHX16 is its role in modulating the expression of other genes. It has been shown to interact with various transcription factors, including DNA-binding proteins and RNA-binding proteins. DHX16 has been shown to play a role in the Regulation of gene expression, and its dysfunction has been linked to various psychiatric and neurological disorders.

In addition to its role in gene regulation, DHX16 has also been shown to play a role in modulating the activity of other proteins. It has been shown to interact with various enzymes, including RNA-protein interactions, and has been shown to modulate the activity of enzymes involved in neurotransmitter synthesis and metabolism.

DHX16 has also been shown to play a role in modulating the immune response. It has been shown to interact with various immune cell types, including T cells and microglia, and has been shown to modulate the production of immune cells involved in inflammation.

In conclusion, DHX16 is a promising drug target and biomarker for various psychiatric and neurological disorders. Further research is needed to fully understand its function and potential as a therapeutic intervention.

Protein Name: DEAH-box Helicase 16

Functions: Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596)

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