DGKE: Key Regulator of Cellular Processes (G8526)

Target Name: DGKE

NCBI ID: G8526

DGKE: Key Regulator of Cellular Processes

DGKE (Diacylglycerol Kinase, Epsilon 64kDa) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of cellular processes that are essential for the survival and proper functioning of cells.

DGKE is a member of the glycylating enzyme family, which is characterized by the presence of a glycylated active site on the protein. This site is known to play a crucial role in the regulation of cellular processes, including cell signaling, DNA replication, and metabolism.

The DGKE gene was identified and its function was determined through various techniques, such as gene cloning, RNA sequencing, and biochemical assays. DGKE has been shown to play a role in the regulation of cellular processes that are critical for the survival and proper functioning of cells.

One of the most significant functions of DGKE is its role in cell signaling. DGKE is involved in the regulation of several intracellular signaling pathways, including the PI3K/Akt signaling pathway, the TOR signaling pathway, and the Wnt signaling pathway.

DGKE is also involved in the regulation of cellular metabolism and energy homeostasis. It plays a role in the metabolism of fatty acids and in the regulation of the activity of the enzymes that are involved in the citric acid cycle.

In addition to its role in cell signaling and metabolism, DGKE is also involved in the regulation of cellular structure and organization. It plays a role in the regulation of cell adhesion and in the maintenance of the cytoskeleton.

DGKE is a potential drug target and has been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Several studies have shown that DGKE is involved in the regulation of several diseases, including cancer cell growth, neurodegenerative diseases, and cardiovascular diseases.

In conclusion, DGKE is a protein that is expressed in various tissues throughout the body and plays a critical role in the regulation of cellular processes that are essential for the survival and proper functioning of cells. Its role in cell signaling, metabolism, and structure organization makes it a potential drug target and a biomarker for several diseases. Further research is needed to fully understand the functions of DGKE and its potential as a drug target.

Protein Name: Diacylglycerol Kinase Epsilon

Functions: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:19744926, PubMed:22108654, PubMed:21477596, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8626589, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (PubMed:8626589). Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle (PubMed:19744926, PubMed:22108654, PubMed:23274426). Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently (PubMed:22108654)

More Common Targets