DHFR2: A Potential Drug Target and Biomarker (G200895)

Target Name: DHFR2

NCBI ID: G200895

DHFR2: A Potential Drug Target and Biomarker

Dihydrofolate reductase-like protein 1 (DHFR2) is a protein that plays a crucial role in the regulation of folate metabolism. It is a key enzyme in the pathway for the production of DNA and RNA from folate, and its function is essential for the development and maintenance of cellular life. DHFR2 is also involved in the regulation of cell growth, apoptosis, and DNA damage repair. Given its importance for cellular processes, DHFR2 has been identified as a potential drug target and biomarker.

DHFR2 and its Functions

DHFR2 is a 26kDa protein that is expressed in a variety of tissues, including liver, spleen, lung, and kidney. It is primarily localized to the endoplasmic reticulum (ER) and nuclear envelope (NE), and is also found in the cytoplasm. DHFR2 is involved in the folate pathway, which is the central catabolic pathway for the production of cell nucleotides, including DNA and RNA.

DHFR2 functions as an enzyme that catalyzes the conversion of 5-methyl- folate to dimethyl- folate. This conversion is critical for the production of nucleotides that are essential for cellular growth and development. DHFR2 is also involved in the regulation of cell growth, apoptosis, and DNA damage repair.

DHFR2 plays a crucial role in the regulation of cell growth and apoptosis. It is known to be involved in the cell cycle, and it has been shown to play a role in the regulation of cell growth and apoptosis. Studies have shown that DHFR2 is involved in the regulation of cell cycle progression, and that it is involved in the determination of cell fate.

DHFR2 is also involved in the regulation of apoptosis. Studies have shown that DHFR2 is involved in the regulation of apoptosis, and that it plays a role in the development of apoptosis. DHFR2 has been shown to be involved in the regulation of cell death, and it has been shown to play a role in the development of neurodegenerative diseases.

DHFR2 is also involved in the regulation of DNA damage repair. Studies have shown that DHFR2 is involved in the regulation of DNA damage repair, and that it plays a role in the repair of DNA damage in response to oxidative stress. DHFR2 has been shown to be involved in the regulation of DNA repair, and it has been shown to play a role in the development of diseases associated with DNA damage.

DHFR2 as a Potential Drug Target

DHFR2 has been identified as a potential drug target due to its involvement in the regulation of cellular processes that are important for human health. Studies have shown that DHFR2 is involved in the production of nucleotides, which are essential for cellular growth and development. DHFR2 is also involved in the regulation of cell growth, apoptosis, and DNA damage repair, and it has been shown to play a role in the development of a variety of diseases.

DHFR2 is also a good candidate for a biomarker for diseases associated with these processes. For example, DHFR2 has been shown to be involved in the regulation of cell growth and apoptosis, and it has been shown to play a role in the development of neurodegenerative diseases. It is possible that DHFR2 may be involved in the development of these diseases, and therefore it may be a useful biomarker for these diseases.

DHFR2 as a Potential Biomarker

DHFR2 has also been identified as a potential biomarker for diseases associated with the regulation of folate metabolism. Studies have shown that DHFR2 is involved in the production of nucleotides from folate, and it is involved in the regulation of the folate pathway. DHFR2 is also involved in the regulation of cell growth, apoptosis, and DNA damage repair, and it has been shown to play a role in the development of a variety of diseases.

DHFR2 may be a useful biomarker for diseases associated with these processes because it is involved in the regulation of folate metabolism, and it has been shown to play a role in the development of these diseases. It is possible that DHFR2 may be involved in the production of nucleotides from folate

Protein Name: Dihydrofolate Reductase 2

Functions: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR

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