DHPS: A Drug Target / Disease Biomarker (G1725)

Target Name: DHPS

NCBI ID: G1725

DHPS: A Drug Target / Disease Biomarker

DHPS (Dihydroxy-2-phenyl-1-propanone) is a drug target and a biomarker that is derived from the phenol fraction of the plant Extract of Strychium guineense. It is a small molecule that is capable of modulating various cellular processes in the body. DHPS has been shown to have anti-inflammatory and antioxidant properties, which make it an attractive drug candidate for the treatment of various diseases.

One of the key features of DHPS is its ability to interact with various cellular signaling pathways. It has been shown to modulate the activity of multiple signaling pathways, including TGF-β, NF-kappa-B, and HSP70. These signaling pathways are involved in various cellular processes that are important for the development and progression of diseases, such as cancer, neurodegenerative diseases, and inflammatory diseases.

DHPS has also been shown to have neuroprotective properties. It has been shown to protect against neurotoxicity in various cellular models, including neurofibrotic rats and mouse models of Alzheimer's disease. It has also been shown to improve the spatial learning and memory tasks in rats.

DHPS has also been shown to have anti-inflammatory properties. It has been shown to reduce the production of pro-inflammatory cytokines in various cellular models, including mouse models of atherosclerosis and inflammatory bowel disease. It has also been shown to improve the production of anti-inflammatory cytokines in various cellular models.

DHPS has also been shown to have antioxidant properties. It has been shown to reduce the production of reactive oxygen species (ROS) in various cellular models, including the mouse model of oxidative stress. It has also been shown to increase the production of antioxidants in various cellular models, including the human model.

In conclusion, DHPS is a drug target and biomarker that has been shown to have anti-inflammatory and antioxidant properties. It is a small molecule that can interact with various cellular signaling pathways and has the potential to be used for the treatment of various diseases. Further research is needed to fully understand the biological and therapeutic effects of DHPS and to develop safe and effective treatments.

Protein Name: Deoxyhypusine Synthase

Functions: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function

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