DHRS4: A Potential Drug Target and Biomarker (G10901)

Target Name: DHRS4

NCBI ID: G10901

DHRS4: A Potential Drug Target and Biomarker

Introduction

Dehydrogenase/reductase (DHRS) family members are a group of enzymes that are involved in the metabolism of various molecules, including small molecules, drugs, and xenobiotics. One of the DHRS family members is DHRS4, which is a promising drug target and biomarker for various diseases. In this article, we will discuss DHRS4, its function, potential drug targets, and potential biomarkers.

Function of DHRS4

DHRS4 is a member of the DHRS family that is involved in the metabolism of various small molecules, including drugs and xenobiotics. It is a protein that is expressed in various tissues, including the brain, heart, liver, and kidney. DHRS4 is involved in the metabolism of a wide range of molecules, including:

* Small molecules, such as drugs, pesticides, and environmental toxins.
* Xenobiotics, such as bacteria, viruses, and fungi.
* Carbonyl compounds, such as lipids and derivatives.

DHRS4 is also involved in the detoxification of xenobiotics and their metabolites. It has been shown to be involved in the metabolism of various xenobiotics, including the anti-inflammatory drug, celecoxib.

Potential Drug Targets

DHRS4 is a potential drug target for various diseases. Its involvement in the metabolism of small molecules, xenobiotics, and carbonyl compounds makes it a potential target for diseases caused by these molecules. Some of the potential drug targets for DHRS4 include:

*Anti-inflammatory drugs, such as celecoxib, that are currently being used to treat inflammatory diseases.
*Environmental pollutants such as pesticides and herbicides, and many other chemicals.
*Lipids and their derivatives, such as fats and fatty acids.

Potential Biomarkers

DHRS4 has also been shown to be involved in various biomarkers for diseases. Its involvement in the metabolism of small molecules, xenobiotics, and carbonyl compounds makes it a potential biomarker for these diseases. Some of the potential biomarkers for DHRS4-related diseases include:

*Early diagnosis of diseases, such as blood sugar levels in diabetics.
*Drug monitoring, such as monitoring drug dosage and effectiveness in clinical trials.
*Evaluate the progress and safety of drug treatment, including assessment of patients' adverse reactions such as pain and nausea.

Conclusion

DHRS4 is a promising drug target and biomarker for various diseases. Its involvement in the metabolism of small molecules, xenobiotics, and carbonyl compounds makes it a potential target for diseases caused by these molecules. Further research is needed to fully understand DHRS4's function and potential as a drug target and biomarker.

Protein Name: Dehydrogenase/reductase 4

Functions: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (PubMed:18571493, PubMed:19056333). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin (PubMed:19056333). Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (PubMed:18571493, PubMed:19056333). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency (PubMed:18571493, PubMed:19056333). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (PubMed:18571493, PubMed:19056333)

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