DHRS12: A Potential Drug Target and Biomarker for the Dehydrogenase/Reductase (SDR) Family

Target Name: DHRS12

NCBI ID: G79758

DHRS12: A Potential Drug Target and Biomarker for the Dehydrogenase/Reductase (SDR) Family

The dehydrogenase/reductase (SDR) family is a diverse superfamily of enzymes that have been implicated in a wide range of physiological processes, including cellular metabolism, signaling pathways, and drug resistance. One of the most promising promising members of this family is DHRS12, a protein that has been shown to play a critical role in multiple cellular processes.

DHRS12 is a member of the SDR family and is found in various organisms, including bacteria, archaea, and eukaryotes. It is a key enzyme in the bacterial electron transport chain, which is responsible for generating ATP through the reduction of electrons from higher energy states to lower energy states. DHRS12 is also involved in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to various diseases, including cancer and neurodegenerative disorders.

DHRS12 functions as a redox enzyme that catalyzes the transfer of a electrons from a acceptor molecule to a precursor molecule. This process involves the formation of a redox pair, which can lead to the production of ROS. DHRS12 also has unique features that distinguish it from other SDR enzymes, such as its catalytic mechanism and its substrate specificity.

Catalytic Mechanism

DHRS12 is a type I SDR enzyme that uses a unique catalytic mechanism to transfer electrons from acceptor molecules to precursor molecules. The catalytic mechanism involves the formation of a redox pair, which is formed by the transfer of an electron from the acceptor molecule to a specific amino acid residue in the precursor molecule.

The catalytic mechanism of DHRS12 is unique because it uses a three-dimensional structure to facilitate the transfer of electrons. DHRS12 has a distinct 尾-sheet and a 尾-hump in its伪-helical region, which allows it to form a stable redox pair. Additionally, DHRS12 has a unique substrate specificity that allows it to selectively interact with certain molecules.

Substrate Specificity

DHRS12 has unique substrate specificity that allows it to selectively interact with certain molecules. It has been shown to be involved in the production of ROS, which can damage cellular components and contribute to various diseases, including cancer and neurodegenerative disorders. DHRS12 has been shown to interact with a variety of molecules, including oxygen, nitrogen, and carbon.

DHRS12 has also been shown to play a critical role in the production of reactive oxygen species (ROS) in response to various stress conditions, such as oxidative stress and radiation damage. It has been shown that the levels of ROS produced by DHRS12 are increased in response to these stress conditions, which can lead to cellular damage and dysfunction.

Drug Target

DHRS12 is a promising drug target because of its unique catalytic mechanism and substrate specificity. The production of ROS by DHRS12 can be inhibited by various small molecules, including antioxidants and anti-inflammatory agents. Additionally, DHRS12 has been shown to be involved in multiple cellular processes, including cell signaling, DNA replication, and cell division. This makes it an attractive target for drug development because of its potential impact on a wide range of cellular processes.

Biomarker

DHRS12 has been shown to be involved in the production of ROS, which can be used as a biomarker for various diseases. The levels of ROS produced by DHRS12 are increased in response to various stress conditions, such as oxidative stress and radiation damage. This makes it an attractive target for the development of biomarkers for diseases that are characterized by the production of ROS.

Conclusion

DHRS12 is a promising drug target and biomarker for the SDR family. Its unique catalytic mechanism and substrate specificity make it an attractive target for drug development. The production of ROS by DHRS12 can be inhibited by various small molecules, which makes it an attractive target for the development of biomarkers for diseases that are characterized by the production of ROS. Further research is needed to fully understand the role of DHRS12 in cellular processes and its potential as a drug target

Protein Name: Dehydrogenase/reductase 12

Functions: Putative oxidoreductase

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