DHRS1: Potential Drug Target Or Biomarker (G115817)

Target Name: DHRS1

NCBI ID: G115817

DHRS1: Potential Drug Target Or Biomarker

DHRS1 (Dehydrogenase/reductase 1, transcript variant 1) is a gene that encodes a protein involved in the process of hydrogen metabolism. Specifically, it is involved in the reduction of hydrogen to formate, which is a key step in the citric acid cycle, Also known as the Krebs cycle or TCA cycle. This protein is a key player in the production of energy in the cell and is often considered a potential drug target or biomarker.

The DHRS1 gene was first identified in 2005 and has since been shown to be involved in various cellular processes, including metabolism, cell signaling, and neurodegeneration. One of the most significant findings related to DHRS1 is its role in the production of formaldehyde, a toxic compound that can be found in various biological systems, including the brain. Formaldehyde has been linked to a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In addition to its role in formaldehyde production, DHRS1 has also been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism. It has been shown to play a role in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to a number of diseases, including neurodegenerative diseases.

DHRS1 has also been shown to be involved in the regulation of cellular immigration and the maintenance of stem cell properties. These processes are important for the development and maintenance of tissues and organs, and are implicated in a number of diseases, including cancer.

Given its involvement in so many cellular processes, DHRS1 has naturally become a hot spot of research. There are currently several studies being conducted to investigate the role of DHRS1 in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the most significant findings related to DHRS1 is its role in the production of formaldehyde, a toxic compound that can be found in various biological systems, including the brain. formaldehyde has been linked to a number of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In addition to its role in formaldehyde production, DHRS1 has also been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism. It has been shown to play a role in the production of reactive oxygen species (ROS), which can damage cellular components and contribute to a number of diseases, including neurodegenerative diseases.

Another promising aspect of DHRS1 research is its role in the regulation of cellular immigration and the maintenance of stem cell properties. These processes are important for the development and maintenance of tissues and organs, and are implicated in a number of diseases, including cancer.

It is important to note that while DHRS1 has been shown to be involved in a number of cellular processes, more research is needed to fully understand its role in these processes and its potential as a drug target or biomarker. Additionally, the study of DHRS1's role in various diseases, including cancer, neurodegenerative diseases, and developmental disorders, is an ongoing process, and new findings are continuously emerging.

In conclusion, DHRS1 is a gene that encodes a protein involved in the process of hydrogen metabolism and has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and metabolism. It is also involved in the production of formaldehyde and in the regulation of cellular immigration and the maintenance of stem cell properties. Further research is needed to fully understand its role in these processes and its potential as a drug target or biomarker.

Protein Name: Dehydrogenase/reductase 1

Functions: NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro (PubMed:30031147). May have a role in steroid and/or xenobiotic metabolism (PubMed:30031147)

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