DGKZ: A Protein Regulator of Cell Growth and Survival (G8525)

Target Name: DGKZ

NCBI ID: G8525

DGKZ: A Protein Regulator of Cell Growth and Survival

DGKZ, or DAG kinase zeta, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of cell proliferation and survival, and is involved in many important cellular processes. In recent years, researchers have become increasingly interested in DGKZ as a potential drug target or biomarker, due to its unique structure and biology.

DGKZ is a protein that is composed of 21 different amino acid residues. It belongs to the DAG-kinase family, which is a group of proteins that are involved in the regulation of DNA-protein interactions. This family of proteins includes several other well-known proteins, such as DAG-1, DAG-2, and DAG-3.

One of the key functions of DGKZ is its role in the regulation of cell growth and differentiation. DGKZ is involved in the regulation of cell proliferation by promoting the growth of cells and by inhibiting the growth of cells that are no longer needed. This is accomplished through a process called \"apoptosis,\" which is a natural process that helps to remove damaged or unnecessary cells from the body.

DGKZ is also involved in the regulation of cell survival. It helps to prevent the apoptosis of cells by promoting the \"neuronal survival\" of these cells. This is accomplished through a process called \"neuronal stem cell maintenance,\" which involves the production of new neurons that can replace damaged or lost cells.

In addition to its role in cell survival and growth, DGKZ is also involved in the regulation of many other cellular processes. It is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. It is also involved in the regulation of cell migration, which is the process by which cells move from one location to another in the body.

DGKZ is a protein that is expressed in many different tissues and cells throughout the body. It is involved in the regulation of cell growth, differentiation, and survival, and is a potential drug target or biomarker. Further research is needed to fully understand the role of DGKZ in cellular processes and its potential as a drug.

Protein Name: Diacylglycerol Kinase Zeta

Functions: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity)

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