DHDDS: Key Regulator of Protein Synthesis and A Potential Biomarker for Diseases
DHDDS: Key Regulator of Protein Synthesis and A Potential Biomarker for Diseases
Dihydrodolichyl diphosphate (DHDP) is a key regulator of protein synthesis and can influence the levels of protein synthesis in the cell. Dehydrodolichyl diphosphate syntase complex subunit DHDDS is a protein that plays a crucial role in the regulation of DHDP synthesis and stability. This article will discuss DHDDS, its function in the cell, and its potential as a drug target or biomarker.
Function and mechanism
DHDDS is a protein that consists of four subunits: DHDDS1, DHDDS2, DHDDS3, and DHDDS4. It is expressed in various cell types and is involved in the regulation of protein synthesis, stability, and degradation. DHDDS functions by catalyzing the conversion of 2- phosphoglycerate (2-PG) to DHDP. This conversion occurs through a series of interactions between the subunits of DHDDS.
DHDDS has been shown to play a role in the regulation of protein synthesis in various cell types. For example, studies have shown that DHDDS is involved in the regulation of protein synthesis in cancer cells. In addition, DHDDS has also been shown to play a role in the regulation of protein synthesis in the nervous system, where it has been shown to be involved in the regulation of neurotransmitter synthesis and release.
DHDDS is also involved in the regulation of protein stability. Studies have shown that DHDDS plays a role in the stability of various proteins, including actinin and tyrosin. This suggests that DHDDS may be a potential drug target or biomarker for diseases associated with protein misfolding or stability disorders.
DHDP synthesis is a critical step in the regulation of protein synthesis. It is a precursor to many proteins, including cytoskeletal components, enzymes, and signaling proteins. The levels of DHDP can be regulated by various enzymes, including DHDDS.
DHDDS has been shown to play a role in the regulation of DHDP synthesis by interacting with various cellular components. For example, studies have shown that DHDDS can interact with the protein component 7 (P7) to regulate DHDP synthesis. P7 is a protein that is involved in the regulation of cell growth and is composed of multiple domains, including a N-terminal domain that is involved in protein-protein interactions and a C-terminal domain that is involved in DNA binding.
In addition, DHDDS has also been shown to interact with the protein encoded by the gene EIF4F1. This protein is involved in the regulation of protein synthesis and stability and has been shown to interact with DHDDS.
DHDDS as a drug target
DHDDS has been shown to play a role in the regulation of protein synthesis and stability, making it a potential drug target or biomarker for various diseases.
One potential mechanism by which DHDDS can be targeted by drugs is by inhibiting its function as a protein synthesis regulator. This can be done by inhibiting the activity of DHDDS or by blocking its interaction with other cellular components.
Another potential mechanism by which DHDDS can be targeted by drugs is by modifying its stability. This can be done by introducing mutations in DHDDS that alter its stability or by introducing drugs that alter its stability.
In addition, DHDDS can also be targeted by drugs that specifically target its subunits. For example, drugs that inhibit the activity of DHDDS1 or DHDDS3 could potentially be effective in treating diseases associated with these subunits.
DHDDS as a biomarker
DHDDS has also been shown to be involved in the regulation of protein synthesis and stability, which makes it a potential biomarker for various diseases.
One potential use of DHDDS as a biomarker is in the diagnosis of diseases associated with protein synthesis or stability disorders. For example, diseases
Protein Name: Dehydrodolichyl Diphosphate Synthase Subunit
Functions: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394)
More Common Targets
DHDDS-AS1 | DHDH | DHFR | DHFR2 | DHFRP3 | DHH | DHODH | DHPS | DHRS1 | DHRS11 | DHRS12 | DHRS13 | DHRS2 | DHRS3 | DHRS4 | DHRS4-AS1 | DHRS4L1 | DHRS4L2 | DHRS7 | DHRS7B | DHRS7C | DHRS9 | DHRSX | DHTKD1 | DHX15 | DHX16 | DHX29 | DHX30 | DHX32 | DHX33 | DHX34 | DHX35 | DHX36 | DHX37 | DHX38 | DHX40 | DHX57 | DHX58 | DHX8 | DHX9 | DIABLO | Diacylglycerol Acyltransferase (DGAT) | Diacylglycerol kinase | DIAPH1 | DIAPH2 | DIAPH3 | DIAPH3-AS1 | DICER1 | DICER1-AS1 | Dickkopf protein | DIDO1 | DiGeorge syndrome critical region gene 9 | Dimethylaniline monooxygenase [N-oxide-forming] | DIMT1 | DINOL | DIO1 | DIO2 | DIO2-AS1 | DIO3 | DIO3OS | DIP2A | DIP2A-IT1 | DIP2B | DIP2C | DIP2C-AS1 | Dipeptidase | Dipeptidyl-Peptidase | DIPK1A | DIPK1B | DIPK1C | DIPK2A | DIPK2B | DIRAS1 | DIRAS2 | DIRAS3 | DIRC1 | DIRC3 | DIRC3-AS1 | DIS3 | DIS3L | DIS3L2 | DISC1 | DISC1FP1 | DISC2 | Disintegrin and Metalloproteinase domain-containing protein (ADAM) (nospecified subtype) | DISP1 | DISP2 | DISP3 | DIXDC1 | DKC1 | DKFZp434L192 | DKFZp451A211 | DKFZp451B082 | DKFZP586I1420 | DKK1 | DKK2 | DKK3 | DKK4 | DKKL1 | DLAT