Target Name: DENND2A
NCBI ID: G27147
Other Name(s): DENN/MADD domain containing 2A | DENN domain-containing protein 2A | FAM31D | DENND2A variant 1 | DEN2A_HUMAN | OTTHUMP00000212111 | OTTHUMP00000212110 | KIAA1277 | DENN domain containing 2A | DENN domain-containing protein 2A (isoform a) | OTTHUMP00000212109 | DENN domain containing 2A, transcript variant 1

Exploring the Potential Applications of DENND2A as a Drug Target or Biomarker

Abstract:

DENND2A, a protein located in the endoplasmic reticulum (ER), has been identified as a potential drug target and biomarker. Its unique structure and subcellular localization have made it an attractive target for small molecules and antibodies. This article will discuss the current research on DENND2A, its potential drug target status, and its potential as a biomarker for various diseases.

Introduction:

The endoplasmic reticulum (ER) is a complex organell

Protein Name: DENN Domain Containing 2A

Functions: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport

More Common Targets

DENND2B | DENND2C | DENND2D | DENND3 | DENND4A | DENND4B | DENND4C | DENND5A | DENND5B | DENND6A | DENND6B | DENR | DEPDC1 | DEPDC1-AS1 | DEPDC1B | DEPDC4 | DEPDC5 | DEPDC7 | DEPP1 | DEPTOR | DERA | DERL1 | DERL2 | DERL3 | DES | DESI1 | DESI2 | DET1 | DEUP1 | DEXI | DFFA | DFFB | DGAT1 | DGAT2 | DGAT2L6 | DGCR11 | DGCR2 | DGCR5 | DGCR6 | DGCR6L | DGCR8 | DGKA | DGKB | DGKD | DGKE | DGKG | DGKH | DGKI | DGKK | DGKQ | DGKZ | DGKZP1 | DGLUCY | DGUOK | DGUOK-AS1 | DHCR24 | DHCR7 | DHDDS | DHDDS-AS1 | DHDH | DHFR | DHFR2 | DHFRP3 | DHH | DHODH | DHPS | DHRS1 | DHRS11 | DHRS12 | DHRS13 | DHRS2 | DHRS3 | DHRS4 | DHRS4-AS1 | DHRS4L1 | DHRS4L2 | DHRS7 | DHRS7B | DHRS7C | DHRS9 | DHRSX | DHTKD1 | DHX15 | DHX16 | DHX29 | DHX30 | DHX32 | DHX33 | DHX34 | DHX35 | DHX36 | DHX37 | DHX38 | DHX40 | DHX57 | DHX58 | DHX8 | DHX9 | DIABLO | Diacylglycerol Acyltransferase (DGAT)