DENND5B: A Potential Drug Target Or Biomarker (G160518)

Target Name: DENND5B

NCBI ID: G160518

DENND5B: A Potential Drug Target Or Biomarker

DENND5B, also known as DENND5B_HUMAN, is a protein that is expressed in human tissues and has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The protein encoded by the DENND5B gene is a member of the Endoplasmic Reticulum (ER) transmembrane protein (TMP) family, which includes a variety of proteins that play important roles in the regulation of intracellular signaling pathways and the transport of molecules across cell membranes.

One of the unique features of DENND5B is its ability to interact with multiple intracellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. This makes it a promising target for drugs that are designed to disrupt these pathways and prevent the development of cancer or other diseases.

In addition to its potential as a drug target, DENND5B has also been identified as a potential biomarker for several diseases. For example, DENND5B has been shown to be overexpressed in several types of cancer, including breast, ovarian, and colorectal cancer. This suggests that it may be a useful indicator of disease status in these cases.

In addition to its potential clinical applications, DENND5B also has potential as a research tool for studying the underlying mechanisms of disease. For example, researchers have used DENND5B to study the effects of drugs on its expression and stability in cancer cells, as well as its role in cell signaling pathways.

Overall, DENND5B is a protein that has significant potential as a drug target or biomarker for a variety of diseases. Further research is needed to fully understand its role and to develop effective treatments.

Protein Name: DENN Domain Containing 5B

Functions: Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

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