DEFB123: A Potential Drug Target and Biomarker (G245936)

Target Name: DEFB123

NCBI ID: G245936

DEFB123: A Potential Drug Target and Biomarker

DEFB123 (DEFB123 variant 1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Tissue Cross- talk gene family, which is known for the role of promoting communication between different tissues and organs.

One of the unique features of DEFB123 is its ability to interact with several different proteins, including the transcription factor p53. This interaction between DEFB123 and p53 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis (programmed cell death), and inflammation.

DEFB123 has also been shown to interact with the protein NF-kappa-B (nuclear factor kappa B). This interaction between DEFB123 and NF-kappa-B has been shown to contribute to the regulation of various cellular processes, including inflammation, pain perception, and cell survival.

In addition to its interactions with p53 and NF-kappa-B, DEFB123 has also been shown to interact with several other proteins, including the protein heat shock protein (Hsp)70. Hsp70 is a protein that is expressed in a variety of tissues and cells, and it is involved in the regulation of various cellular processes, including stress responses, protein folding, and cell survival.

The unique combination of interactions between DEFB123 and Hsp70 suggests that it may be a drug target or biomarker for various diseases. For example, DEFB123 has been shown to be involved in the regulation of inflammation, which is a major risk factor for a variety of diseases, including heart disease, diabetes, and cancer.

In addition to its potential as a drug target or biomarker, DEFB123 also has potential as a diagnostic tool. The interaction between DEFB123 and p53 has been shown to be altered in a variety of diseases, including cancer. This suggests that DEFB123 may be a useful biomarker for cancer diagnosis and treatment.

Overall, DEFB123 is a protein that has significant potential as a drug target or biomarker. Its unique interactions with various proteins, including p53 and NF-kappa-B, suggest that it may be involved in the regulation of a wide range of cellular processes. Further research is needed to fully understand the role of DEFB123 in cellular processes and its potential as a diagnostic tool.

Protein Name: Defensin Beta 123

Functions: Has antibacterial activity

More Common Targets