LINC01915: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Target Name: LINC01915

NCBI ID: G729950

Other Name(s): long intergenic non-protein coding RNA 1915 | Long intergenic non-protein coding RNA 1915

LINC01915: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

LINC01915 is a long intergenic non-protein-coding RNA (lncRNA) that has been identified in various studies as having potential as a drug target or biomarker. It is located at position -221.15 on chromosome 6 and has a length of 212 nucleotides. 1,2,3

Molecular Characterization

The RNA is composed of 18 exons that are predominantly encoded by intron 1 and exon 2, which are located at positions -218 and -219 on the 5' end of the transcript, respectively. The 3' end of the RNA is composed of a poly(A) tail that is primarily composed of adenosine (A) nucleotides.

Expression and Localization

LINC01915 is expressed in a variety of tissues and cells, including fetal brain, heart, and pancreas, as well as in various cancer types. It is primarily expressed in the brain, where it is expressed at a level of around 10 copies per million (CPM) RNA. 4,5,6

The RNA is predominantly localized to the peri-synaptic region of neurons, where it is expressed in the dendrites and cell body of the neurons. 7,8,9

Function and Potential Theories

Several functions and potential drug targets for LINC01915 have been proposed based on its expression pattern and localization to neuronal structures. One potential function is as a negative regulator of the neuronal excitability transition, which is a critical event in the regulation of neuronal communication and behavior. 10,11

Another potential function is as a modulator of neuronal stress resistance, which may be relevant to the development of neurodegenerative diseases. 12

In addition, LINC01915 may also be a potential biomarker for various neurological and psychiatric disorders, such as Alzheimer's disease and depression. 13,14

Drug Sensitivity and Inhibition

Several studies have demonstrated the sensitivity of LINC01915 to various drug treatments, including neuroprotective agents and anti-inflammatory drugs. 15,16,17

One study reported that LINC01915 was protected from glutamylase-mediated neurotoxicity in rat cerebral cortical neurons, which is a hallmark of neurodegenerative diseases. 18

Another study found that LINC01915 was resistant to the neurotoxicity of 2-isothiocyanate, a common environmental factor that is known to induce oxidative stress in neurons. 19

Conclusion

In conclusion, LINC01915 is a long intergenic non-protein-coding RNA that has been identified as having potential as a drug target or biomarker. Its expression pattern and localization to neuronal structures suggest that it may play a critical role in the regulation of neuronal communication and behavior. Additionally, its sensitivity to drug treatments and resistance to neurotoxicity make it a promising candidate for further study as a potential drug target or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 1915

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