Unveiling The Potential Drug Target and Biomarker UCN1_HUMAN (G7349)

Target Name: UCN

NCBI ID: G7349

Unveiling The Potential Drug Target and Biomarker UCN1_HUMAN

Unveiling the Potential Drug Target and Biomarker UCN1_HUMAN: Unraveling the Mysteries of an Uncommon G protein-Coupled Receptor

Introduction

Unconventional Cryptocytosis Nucleotide (UCN) has been thrilling the scientific community with its unique mechanism of action and potential implications in various biological processes. Recently, the discovery of the human protein UCN1_HUMAN has piqued the interest of researchers, providing new insights into the biology of this emerging drug target and biomarker. In this article, we will delve into the molecular world of UCN1_HUMAN, unravel its functions, and explore its potential as a drug target and biomarker.

Molecular Background

UCN1_HUMAN, also known as G protein-Coupled Receptor (GPCR), is a 70kDa protein that plays a crucial role in cell signaling and pharmacology. GPCR is a family of transmembrane proteins that regulate various cellular processes, including cell adhesion, migration, and survival. GPCRs are involved in many essential physiological processes, including sensory perception, neurotransmission, and hormone signaling.

The UCN1_HUMAN gene was first identified in 2002 and is located on chromosome 7p11.2. It encodes a 191 amino acid protein with a calculated pI of 9.95 nM. The protein displays a unique feature, an N-terminal extracellular domain, which is not typical for GPCRs.

Function and Interaction

The primary function of UCN1_HUMAN is to regulate the activity of the neurotransmitter glutamate (GABA), which is involved in various cellular processes, including anxiety, learning, and memory. GABA is a light chain neurotransmitter that acts as an inhibitor , modulating the activity of other neurotransmitters and ion channels.

In addition to its role in GABA signaling, UCN1_HUMAN is also involved in the regulation of cell adhesion and migration, neurogenesis, and neuroprotection. These functions are critical for the maintenance of neural tissue homeostasis and the development , maintenance, and progression of neural circuits.

The interaction of UCN1_HUMAN with GABA is a complex process that involves multiple interactions. The N-terminal region of the protein contains a putative GABA-binding site, which is essential for the protein's GABA-mediated signaling. The putative GABA-binding site is located at the center of the protein and is composed of multiple conserved domains, including a nucleotide-binding oligomerization domain (NBO), a zinc finger, and a putative 伪-helix.

The C-terminal region of UCN1_HUMAN contains a unique feature, a variable region that is involved in the formation of a GABA-like structure. This variable region is composed of a critical region (residues 244-252) and a variable region (residues 253-264). The critical region is thought to play a crucial role in the formation of the GABA-like structure, allowing for the formation of a stable complex between UCN1_HUMAN and GABA.

Drug Target and Biomarker

The unique function of UCN1_HUMAN in regulating GABA signaling and its potential as a drug target make it an attractive target for the development of new therapies for various neurological and psychiatric disorders.

The identification of potential drug targets in GPCR systems is an ongoing process that involves the use of various screening strategies, including high-throughput screening assays, protein fragment complementation assays, and bioinformatics analysis. Several studies have identified potential drug targets in GPCR systems, including those involved in

Protein Name: Urocortin

Functions: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity)

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