UNC119B: A Potential Drug Target and Biomarker (G84747)

Target Name: UNC119B

NCBI ID: G84747

UNC119B: A Potential Drug Target and Biomarker

UNC119B (POC7 centriolar protein homolog B) is a protein that is expressed in various cell types of the human body, including neurons, muscle cells, and red blood cells. It is a member of the POC7 gene family, which is known for the presence of a conserved catalytic core and a transmembrane region in many organisms.

UNC119B is a 166 amino acid protein that has a calculated molecular weight of 19.1 kDa. It has a single transmembrane domain and a calculated pI of 7.4. UNC119B is a cytoplasmic protein, which means that it is located in the cytoplasm of the cell, and is not associated with any specific intracellular structure.

UNC119B is involved in various cellular processes that are important for cell survival and growth. One of its functions is to regulate mitochondrial function, which is critical for the production of energy by the cell. UNC119B is known to interact with the mitochondrial protein known as Complex I, which is involved in the citric acid cycle.

In addition to its role in mitochondrial function, UNC119B is also involved in the regulation of cell adhesion and migration. It has been shown to play a role in the development and maintenance of neural stem cells, which are important for the development and repair of the nervous system.

UNC119B is also a potential drug target and biomarker. Several studies have suggested that UNC119B may be a useful target for small molecule inhibitors, such as those that can inhibit its mitochondrial function. Additionally, UNC119B has been shown to be expressed in various diseases, including cancer, which suggests that it may be a useful biomarker for these diseases.

In conclusion, UNC119B is a protein that is involved in various cellular processes that are important for cell survival and growth. Its role in mitochondrial function and cell adhesion/migration makes it a potential drug target and biomarker. Further research is needed to fully understand its function and potential as a drug.

Protein Name: Unc-119 Lipid Binding Chaperone B

Functions: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells

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