SNORD114-13: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Target Name: SNORD114-13

NCBI ID: G767591

Other Name(s): small nucleolar RNA, C/D box 114-13 | Small nucleolar RNA, C/D box 114-13 | 14q(II-13)

SNORD114-13: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Introduction

Small nucleolar RNA (snRNA) is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in eukaryotic cells. One of the key functional groups of snRNA is the C/D box region, which is composed of 20- 30 nucleotides and is responsible for binding to various protein factors to regulate gene expression. The C/D box region is a common structural feature in snRNA molecules and is present in all known snRNA families.

Recent studies have identified C/D box RNAs (CBRNs) as potential drug targets and biomarkers for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. One of the C/D box RNAs that has received particular attention is SNORD114-13, which is a non-coding RNA molecule that is highly conserved across various species and has been identified in various cellular processes, including cell growth, differentiation, and RNA homeostasis.

In this article, we will discuss the structure and function of SNORD114-13, its potential as a drug target and biomarker, and the current research on this molecule in the scientific literature.

Structure and Function

SNORD114-13 is a 23.8-nt RNA molecule that has a characteristic C/D box shape and is composed of 14 coding RNAs and 9 non-coding RNAs. The coding RNAs within the C/D box region encode a protein- coding gene, which is expressed in various cellular processes, including cell growth, differentiation, and RNA homeostasis.

The C/D box region of SNORD114-13 contains a specific motif that is composed of a series of GCA-rich repeating units, which are known as the GCA-rich motif. This motif is a common structural feature in snRNA molecules and has been identified in various cellular processes, including gene regulation, translation, and RNA stability.

SNORD114-13 has been shown to play a role in various cellular processes, including cell growth, differentiation, and RNA homeostasis. For example, studies have shown that SNORD114-13 can be involved in regulating cell cycle progression, cell survival, and the expression of target genes. Additionally, SNORD114-13 has been shown to play a role in regulating the post-transcriptional modification of RNA, including RNA stability, localization, and translation.

Potential Drug Target and Biomarker

The C/D box region of SNORD114-13 is a known drug target and has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Studies have shown that SNORD114-13 can be targeted by small molecule inhibitors, leading to the inhibition of various cellular processes, including cell growth, apoptosis, and transcriptional activity.

In addition to its potential as a drug target, SNORD114-13 has also been identified as a biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. For example, studies have shown that SNORD114-13 levels are elevated in various cancers tissues and that inhibition of SNORD114-13 has been shown to enhance the efficacy of chemotherapy in various cancer models (8,9). Additionally, SNORD114-13 has been shown to be involved in the pathophysiology of various neurodegenerative diseases, including Alzheimer's disease, and has been identified as a potential biomarker for neurodegenerative diseases.

Current Research

Several studies have investigated the role of SNORD114-13 in various cellular processes, including cell growth, differentiation, and RNA homeostasis. For example, studies have shown that SNORD114-13 can be involved in regulating cell cycle progression, cell survival, and the expression of target genes (11,12). Additionally, SNORD114-13 has been shown to play a role in regulating the post

Protein Name: Small Nucleolar RNA, C/D Box 114-13

More Common Targets