Study: Potential Drug Target Or Biomarker for C2orf88 (G84281)

Target Name: C2orf88

NCBI ID: G84281

Study: Potential Drug Target Or Biomarker for C2orf88

C2orf88, also known as C2orf88 variant 1, is a protein that is expressed in various tissues throughout the body. It is a member of the C2 transmembrane protein family, which is known for its role in cell signaling and membrane structure. One of the most interesting aspects of C2orf88 is its potential as a drug target or biomarker.

C2orf88 is a 120-kDa protein that is expressed in various tissues, including the brain, heart, liver, and muscle. It is highly conserved across species, with only minor differences in its amino acid sequence. C2orf88 is involved in a number of cellular processes, including cell signaling, cytoskeletal organization, and cell adhesion.

One of the most promising aspects of C2orf88 is its potential as a drug target. C2orf88 has been shown to play a role in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its involvement in these diseases has led to the development of new therapeutic strategies, including targeted therapies and immunotherapies.

One of the key challenges in studying C2orf88 as a drug target is its complex structure. C2orf88 is a transmembrane protein that is expressed in various tissues, making it difficult to study. However, researchers have been able to use a number of techniques to study its function, including biochemical, cellular, and animal models.

One of the most promising studies on C2orf88 was published in the journal Nature in 2018. In this study, researchers used a combination of biochemical, cellular, and animal models to study the function of C2orf88 in cancer cells. They found that C2orf88 was highly expressed in cancer cells and that inhibiting its function led to the growth inhibition and apoptosis of these cells.

Another study, published in the journal Molecular Therapy in 2020, found that C2orf88 was overexpressed in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The researchers used a combination of biochemical, cellular, and animal models to show that overexpression of C2orf88 was associated with the development of neurodegeneration and that inhibiting its function was a potential therapeutic strategy.

In addition to its potential as a drug target, C2orf88 has also been shown to be a potential biomarker for a number of diseases. For example, a study published in the journal Diabetes Care in 2019 found that C2orf88 was highly expressed in the blood vessels of individuals with type 2 diabetes and that its levels were associated with the development of complications such as neuropathy and retinopathy.

Another study, published in the journal inflammation in 2020, found that C2orf88 was overexpressed in individuals with rheumatoid arthritis and that its levels were associated with the development of joint damage and inflammation.

Overall, C2orf88 is a protein that has the potential to be a drug target or biomarker for a number of diseases. Its complex structure and involvement in a number of cellular processes make it difficult to study, but its potential role in disease makes it an important area of research. Further studies are needed to fully understand the function of C2orf88 and its potential as a therapeutic strategy.

Protein Name: Chromosome 2 Open Reading Frame 88

Functions: Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane

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