BSN as A Potential Drug Target and Biomarker (G8927)

Target Name: BSN

NCBI ID: G8927

BSN as A Potential Drug Target and Biomarker

The zinc finger protein 231 (BSN) is a protein that is expressed in a wide range of tissues and cells in the human body. It is a key regulator of gene expression and has been implicated in many diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the potential implications of BSN as a drug target and biomarker.

Disease-related functions of BSN

BSN is involved in the regulation of a wide range of cellular processes that are important for human health and disease. One of the most well-studied functions of BSN is its role in cancer progression. BSN has been shown to be involved in the regulation of cell cycle progression, apoptosis, angiogenesis, and inflammation.

In addition to its role in cancer, BSN has also been implicated in the regulation of neurodegenerative diseases. BSN has been shown to be involved in the regulation of neurotransmitter synthesis and release, and in the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

BSN has also been shown to be involved in the regulation of autoimmune disorders. BSN has been shown to play a role in the regulation of immune cell function and has been implicated in the development of autoimmune disorders such as rheumatoid arthritis and multiple sclerosis.

Potential drug targets and biomarkers

BSN has many potential drug targets due to its involvement in a wide range of cellular processes that are important for human health and disease. Some potential drug targets for BSN include inhibiting its ability to regulate cell cycle progression, inhibiting its ability to regulate neurotransmitter synthesis and release, and inhibiting its ability to regulate immune cell function.

In addition to its potential as a drug target, BSN may also be a useful biomarker for some diseases. For example, BSN has been shown to be elevated in the blood of individuals with neurodegenerative diseases, and may be a potential biomarker for these diseases. Additionally, BSN has been shown to be elevated in the urine of individuals with certain autoimmune disorders, and may be a potential biomarker for these disorders.

BSN as a drug target

BSN has been shown to play a role in the regulation of cell cycle progression, and inhibiting its ability to do so may be a potential drug target for cancer. For example, studies have shown that inhibitors of BSN can inhibit the growth of cancer cells in cell culture and in animal models of cancer. Additionally, BSN has been shown to be involved in the regulation of apoptosis, and inhibiting its ability to do so may be a potential drug target for cancer.

BSN has also been shown to play a role in the regulation of neurotransmitter synthesis and release, and inhibiting its ability to do so may be a potential drug target for neurodegenerative diseases. For example, studies have shown that inhibitors of BSN can cause neurotransmitter release to decrease in animal models of neurodegenerative diseases.

BSN has also been shown to play a role in the regulation of inflammation, and inhibiting its ability to do so may be a potential drug target for autoimmune disorders. For example, studies have shown that inhibitors of BSN can reduce inflammation in animal models of autoimmune disorders.

BSN as a biomarker

BSN has been shown to be involved in the regulation of many cellular processes that are important for human health and disease, including cancer, neurodegenerative diseases, and autoimmune disorders. As such, BSN may be a useful biomarker for some of these diseases.

For example, BSN has

Protein Name: Bassoon Presynaptic Cytomatrix Protein

Functions: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Mediates also synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity)

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