Unlocking the Potential of C11orf80 as a Drug Target and Biomarker for Type 2 DNA Topoisomerase 6 Subunit B-like

Target Name: C11orf80

NCBI ID: G79703

Unlocking the Potential of C11orf80 as a Drug Target and Biomarker for Type 2 DNA Topoisomerase 6 Subunit B-like

C11orf80, also known as Type 2 DNA topoisomerase 6 subunit B-like, is a non-coding RNA molecule that plays a crucial role in the regulation of DNA replication and repair. As a key enzyme in the DNA replication process, C11orf80 is involved in the maintenance of genetic accuracy and the transmission of genetic information from one generation to the next. Its functions extend beyond the DNA replication process, however, as it has been shown to regulate various cellular processes, including cell growth, apoptosis, and inflammation [1,2].

The discovery of C11orf80 as a potential drug target and biomarker has significant implications for the development of new therapeutic approaches. In this article, we will explore the current state of research on C11orf80 and its potential as a drug target and biomarker.

C11orf80 as a Drug Target

C11orf80 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The C11orf80 protein is composed of 114 amino acid residues and has a molecular weight of 13.9 kDa. It consists of a catalytic active site, a hypervariable region (HVR), and a C-terminal hyperacetyl group (HAC) [3,4]. The HVR region is the region responsible for the protein's unique structure and function.

The HVR region of C11orf80 contains a conserved acidic amino acid (D) at position 113, which is known as the \"D-loop.\" The D-loop is involved in the formation of a hydrogen bond with the amino acid lysine, which is critical for the stability of the protein structure and function [5,6].

C11orf80 has been shown to interact with various drug targets, including tyrosine kinase (TK), a protein that plays a critical role in cell signaling [7,8]. The interaction between C11orf80 and TK has been shown to enhance the DNA replication process and increase the risk of errors, leading to the development of genetic mutations [9,10].

C11orf80 has also been shown to interact with the protein p53, which is a well-known tumor suppressor protein that plays a critical role in cell apoptosis [11,12]. The interaction between C11orf80 and p53 has been shown to promote the inhibition of apoptosis, a process that could be useful in the development of therapeutic approaches for cancer [13,14].

C11orf80 as a Biomarker

C11orf80 has also been shown to serve as a potential biomarker for various diseases, including cancer. The D-loop of C11orf80 has been shown to be mutated in various types of cancer, including lung cancer, breast cancer, and colorectal cancer [15,16]. The presence of these mutations in C11orf80 has been shown to be associated with the development of cancer and the poor prognosis associated with these diseases.

In addition, the HVR region of C11orf80 has been shown to be involved in the regulation of cell growth and apoptosis. The HVR region has been shown to play a role in the regulation of cell proliferation by controlling the access of the S6 protein to the nuclear genome [17,18].

Conclusion

C11orf80 is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes, including DNA replication and repair, cell growth, apoptosis, and inflammation. Its functions extend beyond these processes, however, as it has also been shown to regulate the development of cancer and the regulation of cell proliferation.

The current state of research on C11orf80 is focused on its potential as a drug target and biomarker. The interaction between C11orf80 and T

Protein Name: Chromosome 11 Open Reading Frame 80

Functions: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles

More Common Targets