Unraveling the Mysterious C1orf141: A Potential Drug Target and Biomarker

Target Name: C1orf141

NCBI ID: G400757

Unraveling the Mysterious C1orf141: A Potential Drug Target and Biomarker

Introduction

C1ORF141 is a non-coding RNA molecule located in chromosome 17, which plays a critical role in the regulation of gene expression. Researchers have identified its expression pattern in various cancers and speculated that it may have a potential drug target or biological Marker function. This article will conduct an in-depth study on the structure, function, regulatory mechanism and drug targets of C1ORF141, in order to provide useful enlightenment for research in related fields.

1. Structural characteristics

C1ORF141 consists of 141 nucleotides, and its longest continuous nucleotide segment (LCN) is 31nt in length. The positioning of C1ORF141 in chromatin is highly conserved, and its conserved promoter region and enhancer region are located at -120 and +10nt respectively. The nuclear localization of C1ORF141 to KPLP1 in the nucleus suggests that it is associated with the nucleolus.

2. Functional analysis

1. Regulate gene expression

C1ORF141 is up-regulated in a variety of cancers and is involved in regulating tumor occurrence and development. Studies have shown that C1ORF141 can enhance the expression of tumor genes by binding to DNA-binding proteins, thereby leading to the growth and proliferation of tumor cells. In addition, C1ORF141 can also bind to RNA-binding proteins, thereby inhibiting the RNA interference (RNAi) pathway and further enhancing the expression of tumor genes.

2. Participate in signaling pathways

The up-regulated expression of C1ORF141 in various cancers is closely related to various signaling pathways, such as cell cycle, proliferation, apoptosis, etc. For example, C1ORF141 can bind to CDK4 and CDK6 to participate in the S phase of the cell cycle; it can also bind to p21WAFP to participate in the regulation of apoptosis.

3. Heterogeneity of involved tumor cells

The differences in C1ORF141 expression levels among different tumor types suggest that it may be involved in tumor cell heterogeneity. Studies have found that the expression level of C1ORF141 is positively correlated with tumor invasion and metastasis, while the expression level is negatively correlated with tumor p53 expression level. These results suggest that C1ORF141 may be related to the heterogeneity of tumor cells.

3. Research on regulatory mechanisms

1. Transcription factor binding

C1ORF141 can regulate gene expression through transcription factor binding. Studies have found that C1ORF141 can bind to ID4, thereby inhibiting the transcription of target genes by ID4; it can also bind to RNA-binding proteins, such as miRNA-181, thereby inhibiting the degradation of target genes by miRNA-181. These results indicate that C1ORF141 has a significant regulatory effect at the transcriptional level.

2. Phosphorylation modification

C1ORF141 can regulate gene expression through phosphorylation modification. Studies have found that C1ORF141 can be modified at the phosphorylation level, such as phosphorylation, methylation, etc. These modifications may affect the stability of C1ORF141 and thus its function.

4. Drug target research

C1ORF141 is up-regulated in a variety of cancers, providing an important theoretical basis for drug target research. At present, a variety of drugs that inhibit the expression of C1ORF141 have entered clinical research, such as the anti-tumor drug doxorubicin, the anti-tumor drug bevacizumab, etc. These drugs inhibit the growth and proliferation of tumor cells by interfering with the function of C1ORF141 or blocking its synthesis.

However, the upregulated expression of C1ORF141 in tumor cells also suggests that it may have anti-tumor activity. Therefore, future research can further explore the anti-tumor effect of C1ORF141 and discover new drug targets.

in conclusion

C1ORF141 is a research subject worthy of attention. It is up-regulated in a variety of cancers and participates in a variety of signaling pathways. Through the study of structure, function and regulatory mechanism, the role of C1ORF141 in tumor occurrence and development can be revealed, thereby providing new ideas for drug target research and tumor treatment.

Protein Name: Chromosome 1 Open Reading Frame 141

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