C1orf94: A Potential Drug Target and Biomarker for Inflammatory Diseases

Target Name: C1orf94

NCBI ID: G84970

C1orf94: A Potential Drug Target and Biomarker for Inflammatory Diseases

C1orf94, also known as C1ORF94 or CD144, is a protein that is expressed in various tissues throughout the body, including the lungs, heart, liver, and nervous system. Its primary function is to interact with the extracellular matrix (ECM) and contribute to the regulation of cellular adhesion, migration, and invasion. C1rf94 has also been implicated in inflammation and immune responses.

Recent studies have identified C1rf94 as a potential drug target and biomarker for several inflammatory diseases, including arthritis, asthma, and multiple sclerosis. In this article, we will explore the biology and potential therapeutic applications of C1rf94 in greater detail.

The Extracellular Matrix and C1rf94

The extracellular matrix (ECM) is a complex structure that surrounds and supports cells, and it plays a critical role in cell-cell adhesion, migration, and invasion. ECM components include a variety of proteins, such as collagen, elastin, and hyaluronic acid, which provide mechanical tension and support, as well as provide sites for various signaling pathways.

C1rf94 is a member of the transforming growth factor receptor (TGFR) family, which includes proteins that regulate cell growth, differentiation, and survival. C1rf94 is characterized by its unique extracellular domain, which consists of a N-terminal domain that contains a leucine-rich repeat (LRR) and a C-terminal domain that contains a conserved N-terminal translocation domain and a cytoplasmic domain.

The N-terminal domain of C1rf94 is responsible for the formation of a complex with the extracellular domain of the TGF-β receptor, which is a key regulator of ECM-associated signaling pathways. This interaction between C1rf94 and TGF-β is critical for the regulation of cellular processes such as cell adhesion, migration, and invasion.

C1rf94 and Cellular Adhesion

C1rf94 has been shown to play a critical role in the regulation of cell-cell adhesion. Several studies have demonstrated that C1rf94 is involved in the formation of tight junctions, which are a type of cell-cell adhesion structure that is critical for maintaining tissue structure and function.

In addition, C1rf94 has been shown to regulate the activity of cadherins, which are a family of transmembrane proteins that are involved in cell-cell adhesion. Cadherins are known for their ability to mediate the formation of tight junctions, and recent studies have suggested that C1rf94 may be involved in the regulation of cadherin activity.

C1rf94 and Cellular Migration

C1rf94 has also been shown to play a critical role in the regulation of cellular migration. Several studies have demonstrated that C1rf94 is involved in the regulation of cell migration, both in normal tissue development and in the regulation of diseases such as cancer.

In addition, C1rf94 has been shown to interact with the protein vimentin, which is involved in the regulation of cell shape and is a critical component of the cytoskeleton. This interaction between C1rf94 and vimentin may be involved in the regulation of cell migration by affecting the cytoskeleton.

C1rf94 as a Potential Drug Target

The potential therapeutic applications of C1rf94 as a drug target are vast. Due to its involvement in the regulation of cell-cell adhesion, C1rf94 has been identified as a potential target for diseases that are characterized by disruptions in cell-cell adhesion, such as cancer, autoimmune diseases, and neurodegenerative diseases.

In addition, C1rf94 has been shown to play a critical role in the regulation of cellular migration, which is a

Protein Name: Chromosome 1 Open Reading Frame 94

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