C1QL3: A Potential Drug Target and Biomarker (G389941)

Target Name: C1QL3

NCBI ID: G389941

C1QL3: A Potential Drug Target and Biomarker

C1QL3 is a protein that is expressed in various tissues and organs, including the brain, spleen, and Peyer's patches of the small intestine. It is a single-chain protein that contains 215 amino acids and has a molecular weight of 21.9 kDa. C1QL3 is also known as complement C1q like 3 (C1q3) or heat shock protein 70 (HSP70) 70kDa.

The protein encoded by the C1QL3 gene is a member of the HSP70 family, which is a family of cytoplasmic proteins that have the ability to localize and survive in various stress conditions, including hyperthermia, hyperoxia, and radiation. HSP70 proteins are involved in a variety of cellular processes, including stress response, DNA repair, and cell signaling.

C1QL3 has been shown to have a variety of functions in various organisms, including regulating cell signaling pathways, DNA replication, and stress response. For example, studies have shown that C1QL3 can interact with the protein heat shock protein (HSP) to protect against oxidative stress and promote DNA repair in response to thermal stress.

In addition to its functions in stress response, C1QL3 has also been shown to play a role in the regulation of cell signaling pathways. For example, studies have shown that C1QL3 can interact with the protein tyrosine kinase (TK) to regulate the signaling pathway associated with the T cell receptor (TCR). This interaction between C1QL3 and TK has been shown to play a role in the regulation of T cell proliferation and differentiation.

C1QL3 has also been shown to have a variety of potential drug targets. For example, studies have shown that C1QL3 can interact with the protein FAK, which is a protein that is involved in cell signaling pathways and has been implicated in a variety of diseases, including cancer. This interaction between C1QL3 and FAK has led to the hypothesis that C1QL3 may be a drug target for the treatment of cancer.

In addition to its potential drug targets, C1QL3 has also been shown to have potential as a biomarker for a variety of diseases. For example, studies have shown that C1QL3 can be expressed in various tissues and cells and can be used as a marker for the diagnosis of certain diseases, such as cancer.

Overall, C1QL3 is a protein that has a variety of functions in various organisms, including regulating cell signaling pathways and protecting against oxidative stress. Its interaction with the protein heat shock protein (HSP) and potential drug targets make it a promising candidate for further study as a drug target for the treatment of cancer. Further research is needed to fully understand the role of C1QL3 in cellular processes and its potential as a biomarker for disease.

Protein Name: Complement C1q Like 3

Functions: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production (By similarity)

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