top3b: A Promising Drug Target and Biomarker for Cancer Treatment

Target Name: TOP3B

NCBI ID: G8940

top3b: A Promising Drug Target and Biomarker for Cancer Treatment

Cancer is one of the leading causes of morbidity and mortality worldwide, affecting millions of individuals worldwide. The development of new treatments for cancer has become a major focus in the pharmaceutical industry, and among the most promising targets for cancer therapy are the DNA topoisomerase III (DNA top)尾 proteins. DNA topoisomerase III is a critical enzyme in the DNA replication process that helps ensure the stability of DNA replicas. Abnormalities in DNA topoisomerase III have been implicated in the development and progression of many types of cancer. Therefore, targeting this enzyme provides a unique opportunity to develop new treatments for cancer. In this article, we will discuss the top3b protein, which is a promising drug target and biomarker for cancer treatment.

The Discovery of top3b

top3b is a protein that belongs to the DNA topoisomerase III (DNA top)尾 family. The DNA topoi

Protein Name: DNA Topoisomerase III Beta

Functions: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity

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