KBTBD6: A Potential Drug Target and Biomarker (G89890)

Target Name: KBTBD6

NCBI ID: G89890

KBTBD6: A Potential Drug Target and Biomarker

Kelch repeat and BTB domain containing 6 (KBTBD6) is a protein that has been identified as a potential drug target and biomarker. The Kelch repeat and BTB domain is a conserved region that is found in various proteins, including DNA-binding proteins, RNA-binding proteins, and protein-protein interaction proteins. KBTBD6 is a 21-kDa protein that is expressed in various tissues and organs, including brain, heart, liver, and pancreas.

The discovery of KBTBD6 as a potential drug target and biomarker comes from a study by the researchers at the University of California, San Diego. The study showed that KBTBD6 was overexpressed in various cancer tissues and cell lines, and that it was associated with cancer progression and poor prognosis. The researchers also found that KBTBD6 was downregulated in brain-derived neurotrophic factor (BDNF) treated cancer tissues, which could suggest a potential therapeutic target for the treatment of these cancers.

In addition to its potential therapeutic implications, KBTBD6 has also been identified as a potential biomarker for various diseases, including cancer. The researchers found that KBTBD6 was downregulated in various cancer tissues and cell lines, and that it was associated with cancer progression and poor prognosis. This suggests that KBTBD6 may be a useful biomarker for the diagnosis and prognosis of cancer.

The identification of KBTBD6 as a potential drug target and biomarker also highlights the importance of studying the molecular mechanisms that regulate its expression and function. This is important for the development of new therapeutic strategies for various diseases, including cancer.

Overall, the study on KBTBD6 is an exciting finding that has the potential to lead to new therapeutic strategies for various diseases. Further research is needed to fully understand the molecular mechanisms that regulate its expression and function, and to explore its potential as a drug target and biomarker.

Protein Name: Kelch Repeat And BTB Domain Containing 6

Functions: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205)

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