KCND2: A Potential Drug Target for Dopamine Regulation (G3751)

Target Name: KCND2

NCBI ID: G3751

KCND2: A Potential Drug Target for Dopamine Regulation

KCND2 (KCND2_HUMAN) is a protein that is expressed in various tissues of the human body, including the nervous system, endocrine system, and uveal system. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a crucial role in cellular signaling.

KCND2 is a 21-kDa protein that is expressed in the brain, heart, liver, and pancreas. It is primarily localized to the basal ganglia, which is a part of the nervous system that is responsible for the coordination of movement and emotion.

One of the unique features of KCND2 is its ability to interact with dopamine (D2) receptors. Dopamine is a neurotransmitter that plays a crucial role in the brain, and it is involved in a wide range of physiological processes, including mood regulation, motivation, and reward.

KCND2 has been shown to play a critical role in the regulation of dopamine signaling in the brain. It is a potent positive modulator of the D2 receptor, which means that it increases the activity of the D2 receptor. This increase in activity can lead to a variety of effects, including increased dopamine release and enhanced dopamine sensitivity.

In addition to its role in modulating dopamine signaling, KCND2 has also been shown to play a critical role in the regulation of other neurotransmitters, including GABA (纬-amyloid), a neurotransmitter that is involved in sleep and wakefulness, and glutamate, a neurotransmitter that is involved in learning and memory.

KCND2 is also expressed in various tissues of the endocrine system, including the pancreas, where it is involved in the regulation of insulin secretion. Additionally, it is expressed in the uveal system, where it is involved in the regulation of ovarian function.

Despite its importance in various physiological processes, KCND2 is not yet a drug target or biomarker. There is a need for further research to better understand the role of this protein in the regulation of dopamine signaling and its potential as a drug target.

In conclusion, KCND2 is a protein that plays a critical role in the regulation of dopamine signaling in the brain and endocrine system. Its ability to interact with dopamine (D2) receptors makes it a promising target for future drug development. Further research is needed to better understand the role of this protein in the regulation of dopamine signaling and its potential as a drug target.

Protein Name: Potassium Voltage-gated Channel Subfamily D Member 2

Functions: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity)

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