SNAP91: A Promising Drug Target and Biomarker for Neurodevelopmental Disorders

Target Name: SNAP91

NCBI ID: G9892

SNAP91: A Promising Drug Target and Biomarker for Neurodevelopmental Disorders

SNAP91 (DKFZp781O0519) is a protein that is expressed in various tissues of the body, including the brain. It is a key regulator of the microtubules, which are the structural elements that give cells their shape and movement. Mutations in the SNAP91 gene have been linked to a range of neurodevelopmental and cognitive disorders, including ALS, Parkinson's disease, and Down syndrome.

In addition to its role in cell structure and movement, SNAP91 has also been shown to play a role in several other cellular processes. For example, it has been shown to be involved in the transfer of organelles within cells, and in the regulation of cell division.

Given its involvement in so many cellular processes, SNAP91 is an attractive target for drug development. Researchers have been exploring the potential uses of SNAP91 as a drug for a variety of conditions, including cancer, neurodegenerative diseases, and developmental disorders.

One of the main advantages of SNAP91 as a drug target is its widespread expression in the body. Unlike many other proteins, which are primarily expressed in certain tissues, SNAP91 is expressed in virtually all tissues of the body. This makes it an attractive target for drugs that can be administered to the entire body, rather than just to a specific tissue.

Another advantage of SNAP91 is its ability to interact with a wide range of molecules. Its expression has been shown to be regulated by a variety of factors, including cytokines, chemokines, and other signaling molecules. This makes it an attractive target for drugs that can modulate its expression and activity.

In addition to its potential uses as a drug, SNAP91 is also a potential biomarker for a variety of neurodevelopmental and cognitive disorders. Its expression has been shown to be reduced in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. This makes it an attractive target for drugs that can increase its expression in these conditions.

Overall, SNAP91 is an promising drug target and biomarker for a variety of neurodevelopmental and cognitive disorders. Further research is needed to fully understand its role in these conditions and to develop effective treatments.

Protein Name: Synaptosome Associated Protein 91

Functions: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity)

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