SNORA22: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Target Name: SNORA22

NCBI ID: G677807

Other Name(s): small nucleolar RNA, H/ACA box 22 | SNORA22A | Small nucleolar RNA, H/ACA box 22 | ACA22

SNORA22: A Potential Drug Target and Biomarker for Small Nucleolar RNA

Small nucleolar RNA (snRNA) is a class of non-coding RNAs that play critical roles in various cellular processes, including DNA replication, gene expression, and RNA metabolism. H/ACA box 22 (H/ACA box 22 gene) is a specific snRNA that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The H/ACA box 22 gene is located on chromosome 18q21 and encodes a 22-nt RNA molecule. This RNA molecule is highly conserved across various species, and it has been shown to play a critical role in various cellular processes, including the regulation of gene expression, DNA replication, and RNA metabolism [1,2].

H/ACA box 22 has been shown to be involved in various cellular processes, including the regulation of gene expression and DNA replication. For example, studies have shown that H/ACA box 22 can interact with the protein histamine H1 (H1), which is involved in the regulation of cellular processes such as cell growth, differentiation, and survival [3,4]. Additionally, H/ACA box 22 has been shown to play a role in the regulation of DNA replication, as it has been shown to interact with the DNA replication protein, DNAT2 [5,6].

H/ACA box 22 has also been shown to be involved in the regulation of RNA metabolism. For example, studies have shown that H/ACA box 22 can interact with the protein silencing factor silencing element (SMI-1), which is involved in the regulation of gene expression and can also act as a negative regulator of RNA polymerase II (RNA polymerase II) [7,8]. Additionally, H/ACA box 22 has been shown to play a role in the regulation of microRNA (miRNA) levels, as it has been shown to interact with the miRNA-binding protein miR-18a [9,10].

The potential drug target status of H/ACA box 22 is supported by its function as a negative regulator of RNA polymerase II and its role in the regulation of gene expression. Additionally, its high conservation across various species and its involvement in various cellular processes make it an attractive candidate for drug targeting.

In conclusion, SNORA22 is a small nucleolar RNA that has been shown to play a critical role in various cellular processes. Its potential as a drug target and biomarker makes it an attractive candidate for further research and development.

Protein Name: Small Nucleolar RNA, H/ACA Box 22

More Common Targets