SNORA65: A Small Nucleolar RNA with Potential as a Drug Target or Biomarker

Target Name: SNORA65

NCBI ID: G26783

Other Name(s): small nucleolar RNA, H/ACA box 65 | U65 | Small nucleolar RNA, H/ACA box 65 | RNU65

SNORA65: A Small Nucleolar RNA with Potential as a Drug Target or Biomarker

Small nucleolar RNA (snRNA) is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in eukaryotic cells. One of the key functional groups of snRNAs is the H/ACA box, which is a conserved region that is present in multiple snRNAs. The H/ACA box is involved in the formation of double-stranded RNA structures, which can interact with various protein factors to regulate gene expression. One of the well-known snRNAs that contain the H/ACA box is SNORA65, which has been identified as a potential drug target or biomarker.

In this article, we will provide an overview of SNORA65, including its structure, function, and potential as a drug target or biomarker. We will discuss the current research on SNORA65 and its potential clinical applications.

Structure and Function

SNORA65 is a 24.1-kb RNA molecule that contains a unique H/ACA box at its end. The H/ACA box is a conserved region that is present in multiple snRNAs, including snRNA-182, snRNA-302, and snRNA-154. The H/ACA box is composed of 214 amino acid residues and has a specific structure that consists of a core region and a variable region.

The core region of SNORA65 consists of the A and U nitrogenous base, a GCA start codon, and a GCA stop codon. The variable region consists of several exons that are responsible for encoding the different RNA structures. The variable region includes a stem-loop structure that is formed by the AU and U nitrogenous bases, as well as a 2'-overhang region that is composed of the U nitrogenous base and a G nitrogenous base.

The H/ACA box is located at the end of the SNORA65 molecule and consists of the GCA start codon, the GCA stop codon, and a variable region that encodes the different RNA structures. The H/ACA box is conserved in multiple snRNAs, including snRNA-182 and snRNA-302, but its sequence is highly conserved among different snRNAs.

Function

SNORA65 is involved in the regulation of gene expression by affecting the stability and localization of other snRNAs. One of the well-known functions of SNORA65 is its role in the regulation of microRNA (miRNA) expression. miRNA are small non-coding RNAs that play a role in post-transcriptional gene regulation by binding to specific target mRNAs. SNORA65 has been shown to interact with miRNA-21, a well-known miRNA that plays a role in cell proliferation and survival.

In addition to its role in miRNA regulation, SNORA65 is also involved in the regulation of gene expression by affecting the stability and localization of other snRNAs. One of the well-known functions of SNORA65 is its role in the regulation of snRNA-224, a non-coding RNA molecule that is involved in the regulation of microRNA (miRNA) expression.

Potential as a Drug Target or Biomarker

SNORA65 has been identified as a potential drug target or biomarker due to its unique structure and function. The conservation of the H/ACA box in multiple snRNAs makes it a promising target for small molecule inhibitors. Additionally, the role of SNORA65 in regulating gene expression by affecting the stability and localization of other snRNAs suggests that it may be a useful biomarker for the diagnosis and prognosis of various diseases.

Current

Protein Name: Small Nucleolar RNA, H/ACA Box 65

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